Evidence map›Paper›PMID 28615244›Full record

ArticleAmerican journal of physiology. Renal physiology2017

Stimulation of the pelvic nerve increases bladder capacity in the prostaglandin E

Christopher L Langdale, James A Hokanson, Arun Sridhar, Warren M Grill

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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  9. Stimulation of the pelvic nerve increases bladder capacity in the PGEAmerican journal of physiology. Renal physiology · 2020
    Article
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  12. Detection of Bladder Contractions From the Activity of the External Urethral Sphincter in Rats Using Sparse Regression.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2018
    Article
  13. Stimulation of the sensory pudendal nerve increases bladder capacity in the rat.American journal of physiology. Renal physiology · 2018
    Article
  14. Article
  15. OAB without an overactive bladder in the acute prostaglandin E2 rat model.American journal of physiology. Renal physiology · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Christopher L LangdaleDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.
James A HokansonDepartment of Biomedical Engineering, Duke University, Durham, North Carolina.ORCID 0000-0002-0560-4503
Arun SridharBioelectronics Research and Development, GlaxoSmithKline, Stevenage, United Kingdom.
Warren M GrillDepartment of Biomedical Engineering, Duke University, Durham, North Carolina; warren.grill@duke.edu.
Duke University · USGlaxoSmithKline (United Kingdom) · GB

Funding

Duke KURe ProgramK12DK100024 · NIDDK · DUKE UNIVERSITY · PI Cindy Amundsen · 2013 to 2026
$8.4M
NIDDK NIH HHS K12 DK100024
6 · The paper itself

Abstract

Overactive bladder (OAB) syndrome is a highly prevalent condition that may lead to medical complications and decreased quality of life. Emerging therapies focusing on selective electrical stimulation of peripheral nerves associated with lower urinary tract function may provide improved efficacy and reduced side effects compared with sacral neuromodulation for the treatment of OAB symptoms. Prior studies investigating the effects of pelvic nerve (PelN) stimulation on lower urinary tract function were focused on promoting bladder contractions, and it is unclear whether selective stimulation of the PelN would be beneficial for the treatment of OAB. Therefore our motivation was to test the hypothesis that PelN stimulation would increase bladder capacity in the prostaglandin E

Indexed as

DinoprostoneMuscle ContractionUrodynamicsAnimalsDisease Models, AnimalElectric Stimulation TherapyElectromyographyFemaleHypogastric PlexusMuscle, SmoothPressureRats, Sprague-DawleyRecovery of FunctionTime FactorsUrethraUrinary BladderDinoprostonebladderelectrical stimulationoveractive bladderpelvic nerveprostaglandin E2

Identifiers

PMID28615244
PMCPMC5625104
OpenAlexW2624984301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.