Evidence map›Paper›PMID 28615198›Full record

ArticleJournal of virology2017

Polymorphic Nature of Human T-Cell Leukemia Virus Type 1 Particle Cores as Revealed through Characterization of a Chronically Infected Cell Line.

Morgan E Meissner, Luiza M Mendonça, Wei Zhang, Louis M Mansky

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Precise excision of HTLV-1 provirus with a designer-recombinase.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  4. Article
  5. Article
  6. Molecular Biology and Diversification of Human Retroviruses.Frontiers in virology (Lausanne, Switzerland) · 2022
    Article
  7. Review
  8. Review
  9. Article
  10. An RNA pseudoknot stimulates HTLV-1RNA (New York, N.Y.) · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. The Retrovirus Capsid Core.Sub-cellular biochemistry · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Morgan E MeissnerInstitute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
Luiza M MendonçaInstitute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.
Wei ZhangInstitute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA zhangwei@umn.edu mansky@umn.edu.
Louis M ManskyInstitute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA zhangwei@umn.edu mansky@umn.edu.
University of Minnesota · USUniversity of Minnesota Medical Center · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
Minnesota Training Program in VirologyT32AI083196 · NIAID · UNIVERSITY OF MINNESOTA · PI Louis M Mansky · 2010 to 2026
$3.2M
HTLV-1 Particle Analysis and Gag InteractionsR01GM098550 · NIGMS · UNIVERSITY OF MINNESOTA · PI MANSKY, LOUIS M. · 2012 to 2020
$3.1M
NCI NIH HHS P30 CA077598NIAID NIH HHS T32 AI083196NIGMS NIH HHS R01 GM098550
6 · The paper itself

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 cell-to-cell transmission is dependent on the release of infectious virus particles into the virological synapse. The HTLV-1 particle structure is still poorly understood, and previous studies analyzed viruses produced by transformed lymphocytic cell lines chronically infected with HTLV-1, particularly the MT-2 cell line, which harbors truncated proviruses and expresses aberrant forms of the Gag protein. In this study, we demonstrate that the chronically infected SP cell line harbors a relatively low number of proviruses, making it a more promising experimental system for the study of the HTLV-1 particle structure. We first identified the genomic sites of integration and characterized the genetic structure of the

Indexed as

Virus IntegrationCell LineCryoelectron MicroscopyDeltaretrovirusHumansProvirusesVirioncore morphologycryoelectron microscopyGaghuman retrovirusinfectivityretrovirus assembly

Identifiers

PMID28615198
PMCPMC5533927
OpenAlexW2740074064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.