ArticleBMC genomics2017
Genome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP array.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 72 citations in OpenAlex.
- Integration of GWAS and eQTL analysis reveals regulatory CNVs for fatty acid traits in cattle.iScience · 2026Article
- Multi-omics dissection of the genetic regulation underlying fatty acid composition in cattle.Genome biology · 2025Article
- Transcriptomic and flavor metabolomic exploration of the genetic basis of meat quality and flavor in Tibetan sheep.BMC genomics · 2025Article
- Multiple strategies association revealed functional candidate FASN gene for fatty acid composition in cattle.Communications biology · 2025Article
- Investigation on the pro-aroma generation effects of fatty acids in beef via thermal oxidative models.Food chemistry: X · 2025Article
- Integrating multi-layered biological priors to improve genomic prediction accuracy in beef cattle.Biology direct · 2024Article
- Candidate genes associated with fatty acid compositions in north American Atlantic salmon (Salmo salar).BMC genomics · 2024Article
- Genome-wide selection reveals candidate genes associated with multiple teats in Hu sheep.Animal biotechnology · 2024Article
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- Effects of raw and fermented rapeseed cake on ruminal fermentation, methane emission, and milk production in lactating dairy cows.Animal feed science and technology · 2023Article
- Whole genome sequencing of simmental cattle for SNP and CNV discovery.BMC genomics · 2023Article
- Genomic prediction of carcass traits using different haplotype block partitioning methods in beef cattle.Evolutionary applications · 2022Article
- Genome-Wide Association Study for Udder Conformation Traits in Chinese Holstein Cattle.Animals : an open access journal from MDPI · 2022Article
- The effect of ensiled paulownia leaves in a high-forage diet on ruminal fermentation, methane production, fatty acid composition, and milk production performance of dairy cows.Journal of animal science and biotechnology · 2022Article
- Transcriptional states and chromatin accessibility during bovine myoblasts proliferation and myogenic differentiation.Cell proliferation · 2022Article
- Comparative Transcriptomic Analysis Reveals Diverse Expression Pattern Underlying Fatty Acid Composition among Different Beef Cuts.Foods (Basel, Switzerland) · 2022Article
- Assessing the Genetic Background and Selection Signatures of Huaxi Cattle Using High-Density SNP Array.Animals : an open access journal from MDPI · 2021Article
- Genetic architecture and genomic selection of fatty acid composition predicted by Raman spectroscopy in rainbow trout.BMC genomics · 2021Article
- Validation of the Prediction Accuracy for 13 Traits in Chinese Simmental Beef Cattle Using a Preselected Low-Density SNP Panel.Animals : an open access journal from MDPI · 2021Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFatty acid composition of muscle is an important trait contributing to meat quality. Recently, genome-wide association study (GWAS) has been extensively used to explore the molecular mechanism underlying important traits in cattle. In this study, we performed GWAS using high density SNP array to analyze the association between SNPs and fatty acids and evaluated the accuracy of genomic prediction for fatty acids in Chinese Simmental cattle.
resultsUsing the BayesB method, we identified 35 and 7 regions in Chinese Simmental cattle that displayed significant associations with individual fatty acids and fatty acid groups, respectively. We further obtained several candidate genes which may be involved in fatty acid biosynthesis including elongation of very long chain fatty acids protein 5 (ELOVL5), fatty acid synthase (FASN), caspase 2 (CASP2) and thyroglobulin (TG). Specifically, we obtained strong evidence of association signals for one SNP located at 51.3 Mb for FASN using Genome-wide Rapid Association Mixed Model and Regression-Genomic Control (GRAMMAR-GC) approaches. Also, region-based association test identified multiple SNPs within FASN and ELOVL5 for C14:0. In addition, our result revealed that the effectiveness of genomic prediction for fatty acid composition using BayesB was slightly superior over GBLUP in Chinese Simmental cattle.
conclusionsWe identified several significantly associated regions and loci which can be considered as potential candidate markers for genomics-assisted breeding programs. Using multiple methods, our results revealed that FASN and ELOVL5 are associated with fatty acids with strong evidence. Our finding also suggested that it is feasible to perform genomic selection for fatty acids in Chinese Simmental cattle.
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