Evidence map›Paper›PMID 28615047›Full record

ArticleBMC anesthesiology2017

Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha.

Yasuko Nagasaka, Martin Wepler, Robrecht Thoonen, Patrick Y Sips, Kaitlin Allen, Jan A Graw, Vincent Yao, Sara M Burns, Stefan Muenster, Peter Brouckaert and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving.American journal of physiology. Regulatory, integrative and comparative physiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Yasuko NagasakaDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6259-3388
Martin WeplerDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Robrecht ThoonenDepartment of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Patrick Y SipsDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Kaitlin AllenDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jan A GrawDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Vincent YaoDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sara M BurnsDepartment of Biomedical Molecular Biology, Ghent University, Ghent, Belgium and Inflammation Research Center, VIB, Ghent, Belgium.
Stefan MuensterDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Peter BrouckaertDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Keith MillerDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ken SoltDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Emmanuel S BuysDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Fumito IchinoseDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Warren M ZapolDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. wzapol@mgh.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USGhent University · BE

Funding

Redesigning General Anesthesia (Admin Supp)R01GM104948 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S., BROWN, EMERY N · 2012 to 2016
$4.4M
Role of Soluble Guanylate Cyclase Alpha 1 in Open Angle GlaucomaR01EY022746 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI BUYS, EMMANUEL S · 2012 to 2016
$2.0M
Improving Outcomes in Cardiac Arrest/CPR with Inhaled Nitric OxideR01HL110378 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ICHINOSE, FUMITO · 2012 to 2015
$2.0M
NEI NIH HHS R01 EY022746NHLBI NIH HHS R01 HL110378NIGMS NIH HHS R01 GM104948
6 · The paper itself

Abstract

backgroundVolatile anesthetics increase levels of the neurotransmitter nitric oxide (NO) and the secondary messenger molecule cyclic guanosine monophosphate (cGMP) in the brain. NO activates the enzyme guanylyl cyclase (GC) to produce cGMP. We hypothesized that the NO-GC-cGMP pathway contributes to anesthesia-induced unconsciousness.

methodsSevoflurane-induced loss and return of righting reflex (LORR and RORR, respectively) were studied in wild-type mice (WT) and in mice congenitally deficient in the GC-1α subunit (GC-1

resultsHigher concentrations of sevoflurane were required to induce LORR in GC-1

conclusionCongenital deficiency of GC-1α abolished the ability of sevoflurane anesthesia to increase cGMP levels in the whole brain, and increased the concentration of sevoflurane required to induce LORR. Impaired NO-cGMP signaling raises the threshold for producing sevoflurane-induced unconsciousness in mice.

Indexed as

Anesthetics, InhalationAnimalsBrainGuanosine MonophosphateGuanylate CyclaseMethyl EthersMice, KnockoutReflex, RightingSevofluraneAnesthetics, InhalationGuanosine MonophosphateGuanylate CyclaseMethyl EthersSevofluraneCyclic guanosine monophosphateKnock-out mouseNitric oxideRighting reflexSevofluraneSoluble guanylyl cyclaseVolatile anesthetics

Identifiers

PMID28615047
PMCPMC5471676
OpenAlexW2625623323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.