Evidence map›Paper›PMID 28615028›Full record

Trial reportActa veterinaria Scandinavica2017

Experimentally induced subclinical mastitis: are lipopolysaccharide and lipoteichoic acid eliciting similar pain responses?

Annalisa Elena Jolanda Giovannini, Bart Henricus Philippus van den Borne, Samantha Kay Wall, Olga Wellnitz, Rupert Max Bruckmaier, Claudia Spadavecchia

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta veterinaria Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Annalisa Elena Jolanda GiovanniniDepartment of Clinical Veterinary Medicine, Anesthesiology and Pain Therapy Section, Vetsuisse Faculty, University of Berne, Laenggassstrasse 124, 3012, Berne, Switzerland.
Bart Henricus Philippus van den BorneVeterinary Public Health Institute, Vetsuisse Faculty, University of Berne, Schwarzenburgstrasse 155, 3097, Liebefeld, Switzerland.
Samantha Kay WallVeterinary Physiology, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a, 3012, Berne, Switzerland.
Olga WellnitzVeterinary Physiology, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a, 3012, Berne, Switzerland.
Rupert Max BruckmaierVeterinary Physiology, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a, 3012, Berne, Switzerland.
Claudia SpadavecchiaDepartment of Clinical Veterinary Medicine, Anesthesiology and Pain Therapy Section, Vetsuisse Faculty, University of Berne, Laenggassstrasse 124, 3012, Berne, Switzerland. claudia.spadavecchia@vetsuisse.unibe.ch.ORCID http://orcid.org/0000-0002-1612-6420
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPain accompanying mastitis has gained attention recently as a relevant welfare compromising aspect of disease. Adequate pain recognition and therapy are necessary in the context of a modern and ethically acceptable dairy care. For research purposes mastitis is often induced by intramammary infusion of immunogenic bacterial cell wall components. Lipopolysaccharide (LPS) from Escherichia coli and lipoteichoic acid (LTA) from Staphylococcus aureus are commonly administered to this end. While the immune response to specific immunogenic components has been well characterized, not much is known about their role on the expression of pain indicators. The aim of this study was to trial the effects of an intramammary challenge of LTA or LPS on the degree of pain and discomfort as indicated by both physiological and behavioral variables in cows. The hypothesis was that a similar degree of pain can be identified in LTA as well as in LPS induced mastitis.

resultsOn the challenge day, compared to pre-challenge, total pain index increased for all treatment groups (LPS; LTA and control), the LPS group having significantly higher values than the control group (P = 0.01). Similarly, pain visual analogue scale (VAS) increased significantly in all cows following treatment on the challenge day. Furthermore, compared to baseline, higher VAS were found 3, 4 and 5 h after the challenge in cows of the LPS group (P

conclusionsWhen administered at equipotent doses targeting a standard somatic cell count increase, intramammary LPS seems to be accompanied by a higher degree of pain and discomfort than LTA, as suggested by the modifications of the outcome variables total pain index, VAS, udder edema and milk cortisol.

Indexed as

Animal HusbandryDairyingAnimalsCattleEscherichia coliFemaleLipopolysaccharidesMammary Glands, AnimalMastitis, BovinePainPain MeasurementProspective StudiesStaphylococcus aureusTeichoic AcidsTreatment OutcomeLipopolysaccharideslipoteichoic acidTeichoic AcidsDairy cowLipopolysaccharideLipoteichoic acidMastitisPain

Identifiers

PMID28615028
PMCPMC5471899
OpenAlexW2626275999

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.