ArticleBMC complementary and alternative medicine2017
Copaiba oil-resin (Copaifera reticulata Ducke) modulates the inflammation in a model of injury to rats' tongues.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of copaiba oil-resin on dental sensitivity control and color change after bleaching: A randomized clinical trial.Clinical oral investigations · 2025Trial
- In vitro evaluation of an experimental copaiba oil-resin gel associated with 35% hydrogen peroxide bleaching on bovine enamel.Odontology · 2026Article
- Copaiba Oil-Resin Reduces the Alveolar Bone Damage Triggered by Apical Periodontitis in Rats.International endodontic journal · 2026Article
- Copaiba oil minimizes inflammation and promotes parenchyma re-epithelization in acute allergic asthma model induced by ovalbumin in BALB/c mice.Frontiers in pharmacology · 2024Article
- Evaluation of the biological activities of Copaiba (Frontiers in pharmacology · 2023Article
- Design and Optimization of a Natural Medicine fromPolymers · 2022Article
- Biological Activity of Copaiba in Damage to the Alveolar Bone in a Model of Periodontitis Induced in Rats.Molecules (Basel, Switzerland) · 2022Article
- Anti-inflammatory and wound healing effect of Copaiba oleoresin on the oral cavity: A systematic review.Heliyon · 2022Review
- Chitosan Membrane Containing Copaiba Oil (Polymers · 2021Article
- Anti-Inflammatory Potential of the Oleoresin from the Amazonian TreeVeterinary sciences · 2021Article
- (Molecules (Basel, Switzerland) · 2021Article
- Evaluation of Resin-Based Material Containing Copaiba Oleoresin (Biomolecules · 2020Article
- Safety and Effectiveness of Copaiba Oleoresin (International journal of molecular sciences · 2020Article
- Antibacterial Activity ofBioMed research international · 2019Article
- EFFECT OF COPAIBA OIL IN INTESTINAL MUCOSA OF RATS SUBMITTED TO HYPOVOLEMIC SHOCK.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2019Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe regeneration of integrity and tissue homeostasis after injury is a fundamental property and involves complex biological processes fully dynamic and interconnected. Although there are medications prescribed to accelerate the process of wound healing by reducing the exaggerated inflammatory response, comes the need to search for different compounds of Amazonian biodiversity that can contribute to the acceleration of the healing process. Among these products, the copaiba oil-resin is one of the most prominent feature in this scenario, as they have been reported its medicinal properties.
methodsAiming to evaluate the anti-inflammatory and healing effect of copaiba oil-resin (Copaifera reticulata Ducke) in transfixing injury of rats' tongues first proceeded up the copaiba oil-resin oral toxicity test in 5 male mice to stipulate the therapeutic dose which was established at 200 mg/kg/day. Then it was induced transfixing injury in a total of 15 Wistar rats. The animals were randomly divided into three groups based on the treatment: control group, dexamethasone group and copaiba oil-resin group. After 7 days of treatment, histological slides stained with hematoxylin and eosin was prepared. Immunohistochemistry for CD68 (macrophage marker) was performed and analyzed by the cell counter Image J.
resultsThe acute toxicity test showed that the oil-resin copal has low toxicity. Furthermore, copaiba oil-resin therapy modulates the inflammatory response by decreasing the chronic inflammatory infiltrate, edema and specifically the number of macrophages.
conclusionsThe results indicate the potential of the Amazon region and showed up relevant because therapy with this extract modulates the inflammatory process.
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