ArticleEnvironmental health : a global access science source2017
The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression.
Article in Environmental health : a global access science source, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Chemical disruption of placental thyroid hormone signalling: a systematic review that highlights sex-specific effects.Archives of toxicology · 2026Pooled it
- Review
- Association between gestational arsenic exposure and infant physical development: a prospective cohort study.BMC public health · 2024Article
- Single-cell RNA sequencing reveals placental response under environmental stress.Nature communications · 2024Article
- Long-term effects of prenatal arsenic exposure from gestational day 9 to birth on lung, heart, and immune outcomes in the C57BL/6 mouse model.Toxicology letters · 2023Article
- Maternal nano-titanium dioxide inhalation alters fetoplacental outcomes in a sexually dimorphic manner.Frontiers in toxicology · 2023Article
- Evaluating maternal exposure to an environmental per and polyfluoroalkyl substances (PFAS) mixture during pregnancy: Adverse maternal and fetoplacental effects in a New Zealand White (NZW) rabbit model.The Science of the total environment · 2022Article
- Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats.Frontiers in medicine · 2022Article
- Sex-Specific Effects of Prenatal and Early Life Inorganic and Methylated Arsenic Exposure on Atherosclerotic Plaque Development and Composition in AdultEnvironmental health perspectives · 2021Article
- Relation between in utero arsenic exposure and growth during the first year of life in a New Hampshire pregnancy cohort.Environmental research · 2020Article
- Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study.Environmental health : a global access science source · 2019Article
- Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner.Environmental health : a global access science source · 2019Article
- Endocrine active metals, prenatal stress and enhanced neurobehavioral disruption.Hormones and behavior · 2018Article
- Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease.PloS one · 2018Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundSex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. Increasing evidence suggests that such sex differences also exist during fetal development. In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate in utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. These associations were sex-dependent, suggesting that in utero arsenic exposure differentially impacts male and female fetuses. In the present study, we investigated the molecular basis for these sex-specific responses to arsenic.
methodsUsing NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. Multivariable linear regression analysis was used to examine their relationship with arsenic exposure and with key developmental genes, after stratification by fetal sex.
resultsWe found that maternal arsenic exposure was strongly associated with expression of the AQP9 gene, encoding an aquaglyceroporin transporter, in female but not male fetal placenta. Moreover, AQP9 expression associated with that of a subset of female-specific arsenic-responsive genes.
conclusionsOur results suggest that AQP9 is upregulated in response to arsenic exposure in female, but not male, fetal placenta. Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. Thus, this study suggests that AQP9 may play a role in the sex-specific effects of in utero arsenic exposure.
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