ArticlePharmaceutical biology2017
The effects of triptolide on the pharmacokinetics of sorafenib in rats and its potential mechanism.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- From immunosuppression to immune reprogramming: is triptolide a potential "immune reset" agent in autoimmune diseases?Immunologic research · 2025Review
- Pharmacological, computational, and mechanistic insights into triptolide's role in targeting drug-resistant cancers.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Pharmacokinetic Interactions between Canagliflozin and Sorafenib or Lenvatinib in Rats.Molecules (Basel, Switzerland) · 2022Article
- Oral sorafenib-loaded microemulsion for breast cancer: evidences from the in-vitro evaluations and pharmacokinetic studies.Scientific reports · 2022Article
- Hesperetin mitigates sorafenib-induced cardiotoxicity in mice through inhibition of the TLR4/NLRP3 signaling pathway.PloS one · 2022Article
- Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats.Pharmaceutics · 2021Article
- Baicalin Enhanced Oral Bioavailability of Sorafenib in Rats by Inducing Intestine Absorption.Frontiers in pharmacology · 2021Article
- OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma.Disease markers · 2021Article
- Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism.Pharmaceutical biology · 2020Article
- Effects of puerarin on the pharmacokinetics of astragaloside IV in rats and its potential mechanism.Pharmaceutical biology · 2020Article
- The Influence of Paracetamol on the Penetration of Sorafenib and Sorafenib N-Oxide Through the Blood-Brain Barrier in Rats.European journal of drug metabolism and pharmacokinetics · 2020Article
- Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism.Pharmaceutical biology · 2020Article
- Pharmacokinetic Interaction between Sorafenib and Atorvastatin, and Sorafenib and Metformin in Rats.Pharmaceutics · 2020Article
- In vivo assessment of the drug interaction between sorafenib and paracetamol in rats.Cancer chemotherapy and pharmacology · 2020Article
- Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats.Pharmaceutical biology · 2019Article
- Influence of verapamil on the pharmacokinetics of oridonin in rats.Pharmaceutical biology · 2019Article
- Effects of puerarin on the pharmacokinetics of triptolide in rats.Pharmaceutical biology · 2019Article
- A Pharmacokinetic Interaction Study of Sorafenib and Iced Teas in Rats Using UPLC-MS/MS: An Illustration of Beverage-Drug Interaction.BioMed research international · 2019Article
- Influence of andrographolide on the pharmacokinetics of warfarin in rats.Pharmaceutical biology · 2018Article
- Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism.Pharmaceutical biology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextCombining sorafenib with triptolide could inhibit tumour growth with greater efficacy than single-agent treatment. However, their herb-drug interaction remains unknown.
objectiveThis study investigates the herb-drug interaction between triptolide and sorafenib. MATERIALS AND
methodsThe effects of triptolide (10 mg/kg) on the pharmacokinetics of different doses of sorafenib (20, 50 and 100 mg/kg) in rats, and blood samples were collected within 48 h and evaluated using LC-MS/MS. The effects of triptolide on the absorption and metabolism of sorafenib were also investigated using Caco-2 cell monolayer model and rat liver microsome incubation systems.
resultsThe results showed that the C DISCUSSION AND
conclusionsThese results indicated that triptolide could change the pharmacokinetic profiles of sorafenib in rats; these effects might be exerted via decreasing the intrinsic clearance rate of sorafenib in rat liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.