ArticleMolecules and cells2017
Cell Death-Associated Ribosomal RNA Cleavage in Postmortem Tissues and Its Forensic Applications.
Article in Molecules and cells, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 32 citations in OpenAlex.
- Molecular forensics: RNA degradation as a marker for postmortem interval determination.International journal of legal medicine · 2026Article
- Characteristics of the Cytotoxicity ofInternational journal of molecular sciences · 2022Article
- Postmortem expression of apoptosis-related genes in the liver of mice and their use for estimation of the time of death.International journal of legal medicine · 2021Article
- MicroRNAs as Useful Tools to Estimate Time Since Death. A Systematic Review of Current Literature.Diagnostics (Basel, Switzerland) · 2021Review
- Effect of preservation time of formalin-fixed paraffin-embedded tissues on extractable DNA and RNA quantity.The Journal of international medical research · 2020Article
- Quantitative analysis of noncoding RNA from paired fresh and formalin-fixed paraffin-embedded brain tissues.International journal of legal medicine · 2020Article
- Analysis of RNA in the estimation of post-mortem interval: a review of current evidence.International journal of legal medicine · 2019Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Estimation of postmortem interval (PMI) is a key issue in the field of forensic pathology. With the availability of quantitative analysis of RNA levels in postmortem tissues, several studies have assessed the postmortem degradation of constitutively expressed RNA species to estimate PMI. However, conventional RNA quantification as well as biochemical and physiological changes employed thus far have limitations related to standardization or normalization. The present study focuses on an interesting feature of the subdomains of certain RNA species, in which they are site-specifically cleaved during apoptotic cell death. We found that the D8 divergent domain of ribosomal RNA (rRNA) bearing cell death-related cleavage sites was rapidly removed during postmortem RNA degradation. In contrast to the fragile domain, the 5' terminal region of 28S rRNA was remarkably stable during the postmortem period. Importantly, the differences in the degradation rates between the two domains in mammalian 28S rRNA were highly proportional to increasing PMI with a significant linear correlation observed in mice as well as human autopsy tissues. In conclusion, we demonstrate that comparison of the degradation rates between domains of a single RNA species provides quantitative information on postmortem degradation states, which can be applied for the estimation of PMI.
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