Evidence map›Paper›PMID 28614837›Full record

ReviewNephron2017

Renal Oxygenation and Hemodynamics in Kidney Injury.

Alexander Bullen, Zhi Zhao Liu, Mark Hepokoski, Ying Li, Prabhleen Singh

Open access · bronzeAbstract readReview
In one paragraph

Review in Nephron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Potential Use of Near- and Mid-Infrared Spectroscopy in Kidney Diseases.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alexander BullenDivision of Nephrology-Hypertension, University of California, San Diego School of Medicine and VA San Diego Healthcare System, San Diego, CA, USA.
Zhi Zhao Liu
Mark Hepokoski
Ying Li
Prabhleen Singh
University of California, San Diego · USVA San Diego Healthcare System · US

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CURTIS, LISA M · 2008 to 2022
$18.3M
Renal Oxygenation and Mitochondrial Function in AKIR01DK107852 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SINGH, PRABHLEEN · 2016 to 2020
$1.7M
Adult and Pediatric Nephrology Clinical Investigation Training ProgramT32DK104717 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IX, JOACHIM H · 2016 to 2020
$1.3M
Renal Oxygenation and Hemodynamics in Sepsis Associated Acute Kidney InjuryR03DK101841 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SINGH, PRABHLEEN · 2015 to 2016
$155k
Renal Oxygenation in the Pathophysiology of Kidney DiseaseI01BX002175 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI SINGH, PRABHLEEN · 2015 to 2025
–
BLRD VA I01 BX002175NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK107852NIDDK NIH HHS R03 DK101841NIDDK NIH HHS T32 DK104717
6 · The paper itself

Abstract

Acute kidney injury (AKI) continues to be a major therapeutic challenge. Despite significant advances made in cellular and molecular pathophysiology of AKI, major gaps in knowledge exist regarding the changes in renal hemodynamics and oxygenation in the early stages and through the continuum of AKI. Particular features of renal hemodynamics and oxygenation increase the susceptibility of the kidney to sustain injury due to oxygen demand-supply mismatch and also play an important role in the recovery and repair from AKI as well as the transition of AKI to chronic kidney disease. However, lack of well-established physiological biomarkers and noninvasive imaging techniques limit our understanding of the interactions between renal macro and microcirculation and tissue oxygenation in AKI. Advances in our ability to assess these parameters in preclinical and clinical AKI will enable the development of targeted therapeutics to improve clinical outcomes.

Indexed as

Oxygen ConsumptionRenal CirculationAcute Kidney InjuryHemodynamicsHumansKidneyAcute renal failureHypoxiaRenal hemodynamics

Identifiers

PMID28614837
PMCPMC5732093
OpenAlexW2651524718

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.