Evidence map›Paper›PMID 28614713›Full record

ArticleCell reports2017

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.

Ernie Yulyaningsih, Ivan A Rudenko, Martin Valdearcos, Emma Dahlén, Eirini Vagena, Alvin Chan, Arturo Alvarez-Buylla, Christian Vaisse, Suneil K Koliwad, Allison W Xu

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 51 citations in OpenAlex.

  1. Experimental models in diabetes research.Laboratory animal research · 2026
    Review
  2. Review
  3. Knockdown ofFrontiers in physiology · 2025
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  19. Obesity and endocrine-disrupting chemicals.Endocrine connections · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ernie YulyaningsihDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Ivan A RudenkoDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Martin ValdearcosDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Emma DahlénDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Eirini VagenaDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Alvin ChanDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Arturo Alvarez-BuyllaEli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Christian VaisseDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Suneil K KoliwadDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Allison W XuDiabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: allison.xu@ucsf.edu.
University of California, San Francisco · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
The Melanocortin-4 Receptor in Human ObesityR01DK060540 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2002 to 2026
$7.5M
Obesity in Ciliopathies: How Neuronal Primary Cilia Control AppetiteR01DK106404 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F, VAISSE, CHRISTIAN · 2016 to 2025
$6.6M
Microglia: dietary fat-sensitive mediators of inflammation and metabolic diseaseR01DK103175 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOLIWAD, SUNEIL KRISHNA · 2015 to 2019
$1.8M
Compensatory Regulation of Energy Balance by Neurogenesis in Adult HypothalamusR01DK089094 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI XU, ALLISON W · 2010 to 2014
$1.7M
NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK060540NIDDK NIH HHS R01 DK089094NIDDK NIH HHS R01 DK103175NIDDK NIH HHS R01 DK106404
6 · The paper itself

Abstract

Neurons expressing agouti-related protein (AgRP) are essential for feeding. The majority of these neurons are located outside the blood-brain barrier (BBB), allowing them to directly sense circulating metabolic factors. Here, we show that, in adult mice, AgRP neurons outside the BBB (AgRP

Indexed as

AnimalsBiological TransportBlood-Brain BarrierHypothalamusMiceNeuronsPro-OpiomelanocortinPro-OpiomelanocortinAgRPblood-brain barrierhypothalamusmonosodium glutamaterepair

Identifiers

PMID28614713
PMCPMC5651178
OpenAlexW2625877288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.