ArticleRevista panamericana de salud publica = Pan American journal of public health2017
Persistent arthralgia and related risks factors in laboratory-confirmed cases of Chikungunya virus infection in Mexico.
Article in Revista panamericana de salud publica = Pan American journal of public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Antiviral Activity of Liposomes Containing Natural Compounds Against CHIKV.Pharmaceutics · 2025Article
- Chikungunya virus in Thailand (2020-2023): Epidemiology, clinical features, and genomic insights.PLoS neglected tropical diseases · 2025Article
- Prevalence of Chikungunya, Dengue, and West Nile arboviruses in Iran based on enzyme-linked immunosorbent assay (ELISA): A systematic review and meta-analysis.Global epidemiology · 2025Article
- Chikungunya virus-specific CD4Cell reports. Medicine · 2025Article
- The 8-bromobaicalein alleviated chikungunya-induced musculoskeletal inflammation and reduced the viral load in healthy adult mice.Emerging microbes & infections · 2023Article
- Dengue, chikungunya, and Zika virus infections in Latin America and the Caribbean: a systematic review.Revista panamericana de salud publica = Pan American journal of public health · 2023Review
- A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development.Viruses · 2022Review
- Post-chikungunya arthritis: a longitudinal study in a tertiary care hospital in Bangladesh.Tropical medicine and health · 2022Article
- Chronic Chikungunya Virus Disease.Current topics in microbiology and immunology · 2022Article
- Arthralgia resolution rate following chikungunya virus infection.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Review
- Screening for Depressive Mood During Acute Chikungunya Infection in Primary Healthcare Settings.International journal of environmental research and public health · 2018Article
- Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment.JCI insight · 2018Article
- Smoking and female sex as key risk factors associated with severe arthralgia in acute and chronic phases of Chikungunya virus infection.Experimental and therapeutic medicine · 2018Article
- The Identification of Risk Factors for Chronic Chikungunya Arthralgia in Grenada, West Indies: A Cross-Sectional Cohort Study.Open forum infectious diseases · 2018Article
- Chikungunya: an emerging viral infection with varied clinical presentations in Bangladesh: Reports of seven cases.BMC research notes · 2017Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate the cumulative incidence of persistent arthralgia at 6 months from acute Chikungunya virus (CHIKV) infection and to evaluate the association of clinical markers with the risk of long-term arthralgia.
methodsThis multicenter retrospective cohort study was conducted in the Mexican state of Colima. A total of 136 individuals aged 15 years and older with serologically confirmed CHIKV infection were enrolled. Participants were interviewed at 6 months from the onset of symptoms, and self-reported persistent arthralgia (PA) was the main binary outcome. A self-report numeric rating scale (NRS) ranging from 0 to 10 was used to estimate the severity of articular pain.
resultsThe cumulative incidence of PA was 41.9%. Severe pain (NRS ≥ 7) presented in 36.8% of participants with PA. In multiple analysis, individuals aged 40 years and older (risk ratio (RR) = 1.60; 95% confidence interval (CI), 1.03-2.48) and those with articular pain at 3 months post-infection (RR = 3.95; 95% CI, 1.95-8.01) had a significantly increased risk of PA at 6 months from CHIKV infection.
conclusionsTo the best of our knowledge, this is first report of a CHIKV-associated long-term outcome in Mexico, where the incidence of the infection has been high. This is also the first study in Latin America evaluating several factors associated with the risk of PA. Our findings may be useful in health care settings to stratify the risk of chronic arthralgia secondary to CHIKV infection and to identify patients who would benefit clinically from early medical intervention.
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Identifiers
28614481PMC6645375W2605900815What OpenQuestion holds
Registered trials
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