Evidence map›Paper›PMID 28614399›Full record

Trial reportPloS one2017

The effects of high-frequency rTMS over the left DLPFC on cognitive control in young healthy participants.

Yanmin Li, Lin Wang, Meng Jia, Jihong Guo, Huijun Wang, Mingwei Wang

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06482749 (Impact of Repetitive Transcranial Magnetic Stimulation on Postoperative Neurocognitive Recovery in Older Patients With Preoperative Cognitive Impairment), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06482749 narecruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Repetitive Transcranial Magnetic Stimulation on Postoperative Neurocognitive Recovery in Older Patients With Preoperative Cognitive Impairment: A Randomized, Double-blinded, Sham-controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2029Enrolled568ConditionsOlder Patients, Cognitive Impairment, Repetitive Transcranial Magnetic Stimulation, Delayed Neurocognitive RecoveryArmsRepetitive transcranial magnetic stimulation, Sham stimulation
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  5. Does transcranial direct current stimulation enhance cognitive performance in Parkinson's disease mild cognitive impairment? An event-related potentials and neuropsychological assessment study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yanmin LiDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Lin WangDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Meng JiaDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Jihong GuoDepartment of Neural Electrophysiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Huijun WangDepartment of Neural Electrophysiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Mingwei WangDepartment of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.ORCID http://orcid.org/0000-0002-5729-2222
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large body of evidence suggests that repetitive transcranial magnetic stimulation (rTMS) is clinically effective in treating neuropsychiatric disorders and multiple sessions are commonly used. However, it is unknown whether multiple sessions of rTMS improve cognitive control, which is a function of the neural circuitry of the left dorsolateral prefrontal cortex (DLPFC)-cingulate cortex in healthy individuals. In addition, it is still unclear which stages of neural processing are altered by rTMS. In this study, we investigated the effects of high-frequency rTMS on cognitive control and explored the time course changes of cognitive processing after rTMS using event-related potentials (ERPs). For seven consecutive days, 25 young healthy participants underwent one 10-Hz rTMS session per day in which stimulation was applied over the left DLPFC, and a homogeneous participant group of 25 individuals received a sham rTMS treatment. A Stroop task was performed, and an electroencephalogram (EEG) was recorded. The results revealed that multiple sessions of rTMS can decrease reaction time (RTs) under both congruent and incongruent conditions and also increased the amplitudes of both N2 and N450 compared with sham rTMS. The negative correlations between the mean amplitudes of both N2 and N450 and the RTs were found, however, the latter correlation were restricted to incongruent trials and the correlation was enhanced significantly by rTMS. This observation supports the view that high-frequency rTMS over the left DLPFC can not only recruit more neural resources from the prefrontal cortex by inducing an electrophysiologically excitatory effect but also enhance efficiency of resources to deploy for conflict resolution during multiple stages of cognitive control processing in healthy young people.

Indexed as

Healthy VolunteersAdultAnalysis of VarianceCognitionElectroencephalographyEvoked PotentialsFemaleGyrus CinguliHumansMaleNerve NetNeural ConductionPrefrontal CortexTranscranial Magnetic StimulationYoung Adult

Identifiers

PMID28614399
PMCPMC5470713
OpenAlexW2625286795

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.