ArticlePloS one2017
Barriers and facilitators of adherence to antidepressants among outpatients with major depressive disorder: A qualitative study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 5 of them syntheses that pooled it.
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Who cites it
64 citing papers in PubMed, 5 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Discrete Choice Experiments to Elicit Patient Preferences for the Treatment of Major Depressive Disorder: A Systematic Review.The patient · 2025Pooled it
- What is the impact of antidepressant side effects on medication adherence among adult patients diagnosed with depressive disorder: A systematic review.Journal of psychopharmacology (Oxford, England) · 2024Pooled it
- Experiences of treatment-resistant mental health conditions in primary care: a systematic review and thematic synthesis.BMC primary care · 2022Pooled it
- Nonpharmacological Treatment for Supporting Social Participation of Adults with Depression.Occupational therapy international · 2021Pooled it
- Effects of Transcranial Direct Current Stimulation (tDCS) in the Normalization of Brain Activation in Patients with Neuropsychiatric Disorders: A Systematic Review of Neurophysiological and Neuroimaging Studies.Neural plasticity · 2020Pooled it
- Effect of Adjunctive Simvastatin on Depressive Symptoms Among Adults With Treatment-Resistant Depression: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Navacaprant, a Novel and Highly Selective Kappa Opioid Receptor Antagonist, in Adults With Major Depressive Disorder: A Randomized, Double-Blind Phase 2 Clinical Trial.Journal of clinical psychopharmacologyTrial
- A cross-sectional study of the influence of patient experience and psychological contract on medication adherence in depressive patients.Exploratory research in clinical and social pharmacy · 2026Article
- The Decision-Making Process of Antidepressant Use Among Patients with Depression: A Grounded Theory Study.Patient preference and adherence · 2026Article
- Medication-related burden variation across chronic conditions: a population-based cross-sectional survey.BMC health services research · 2025Article
- Medication adherence, depression levels, and quality of life among young people with depression in Indonesia: a mixed method study.Social psychiatry and psychiatric epidemiology · 2025Article
- Factors Associated with Stigma and Beliefs About Psychotropics Among the Japanese Ancestry Population Diagnosed with Depression in Brazil.Journal of immigrant and minority health · 2025Article
- The Association Between Medication Adherence, Internalized Stigma and Social Support Among Outpatients with Major Depressive Disorder in a Malaysian Hospital: A Cross-Sectional Study.Psychology research and behavior management · 2025Article
- An online evidence-based dictionary of common adverse events of antidepressants: a new tool to empower patients and clinicians in their shared decision-making process.BMC psychiatry · 2024Article
- Perspectives of Community Nurses on Treatment Engagement of Persons with Severe Mental Illnesses (PwSMI): A Qualitative Study from South India.Indian journal of psychological medicine · 2024Article
- Utilization of Cultural Formulation Interview to understand the factors affecting treatment adherence and help-seeking in mood disorders: A qualitative study from Western India.Indian journal of psychiatry · 2024Article
- Effects of pharmacogenomics-guided treatment on medication adherence and the antidepressant switching rate in major depressive disorder.Frontiers in pharmacology · 2024Article
- Challenges and strategies for improving medication adherence among adolescent psychiatric patients: A qualitative study.Global mental health (Cambridge, England) · 2024Article
- Lived experiences of adults' non-compliance with psychiatric medication for depression.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne of the major challenges in treating major depressive disorder (MDD) is patients' non-adherence to medication. This study aimed to explore the barriers and facilitators of patients' adherence to antidepressants among outpatients with MDD.
methodsSemi-structured and individual in-depth interviews were conducted among patients with MDD who were taking antidepressants, in the psychiatric clinic of a government-run hospital in Malaysia. Participants were purposively sampled from different genders and ethnicities. Interviews were conducted using a validated topic guide, and responses were audio-recorded, transcribed verbatim, checked, and analyzed using the grounded theory approach.
resultsA total of 30 patients were interviewed. Forty different themes and sub-themes were identified which were conceptually divided into two distinct categories related to barriers and facilitators to adherence. The barriers were: patient-specific, medication-specific, healthcare provision and system, social-cultural, and logistics. The facilitators were: having insight, perceived health benefits, regular activities, patient-provider relationship, reminders, and social support networks.
conclusionsPatient-specific barriers and medication side effects were the major challenges for adhering to treatment. Perceived health benefits and having insight on the need for treatment were the most frequently cited facilitators. Targeted interventions should be developed to address the key barriers, and promote measures to facilitate adherence in this group of patients.
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