Observational studyMedicine2017
Global regulator SoxR is a negative regulator of efflux pump gene expression and affects antibiotic resistance and fitness in Acinetobacter baumannii.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Drug-resistantClinical microbiology reviews · 2025Pooled it
- Efflux pump activation confers mupirocin resistance and enhances rhizosphere fitness inApplied and environmental microbiology · 2026Article
- In vitro selection of cefiderocol-resistant mutants in Acinetobacter baumannii harbouring the most common carbapenemase genes.The Journal of antimicrobial chemotherapy · 2026Article
- Antimicrobial Resistance and Genomic Characterization of anVeterinary sciences · 2025Article
- Targeting Acinetobacter baumannii resistance-nodulation-division efflux pump transcriptional regulators to combat antimicrobial resistance.npj antimicrobials and resistance · 2025Review
- Evolution of Resistance against Ciprofloxacin, Tobramycin, and Trimethoprim/Sulfamethoxazole in the Environmental Opportunistic PathogenAntibiotics (Basel, Switzerland) · 2024Article
- The tigecycline resistance mechanisms in Gram-negative bacilli.Frontiers in cellular and infection microbiology · 2024Review
- Comparison of antimicrobial activities and resistance mechanisms of eravacycline and tigecycline against clinicalFrontiers in microbiology · 2024Article
- Review
- Functional analysis of bacterial genes accidentally packaged in rhizospheric phageome of the wild plant speciesSaudi journal of biological sciences · 2023Article
- Virulence Traits and Azole Resistance in KoreanJournal of fungi (Basel, Switzerland) · 2023Article
- Abundant resistome determinants in rhizosphere soil of the wild plant Abutilon fruticosum.AMB Express · 2023Article
- Characterization of a Tigecycline-Resistant andApplied and environmental microbiology · 2023Article
- Functional annotation of rhizospheric phageome of the wild plant speciesFrontiers in microbiology · 2023Article
- Resistance mechanisms of tigecycline inFrontiers in cellular and infection microbiology · 2023Review
- Abundant antibiotic resistance genes in rhizobiome of the human edibleFrontiers in microbiology · 2022Article
- Co-Occurrence ofAntibiotics (Basel, Switzerland) · 2021Article
- Article
- Review
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SoxR is a global regulator contributing to multidrug resistance in Enterobacteriaceae. However, the contribution of SoxR to antibiotic resistance and fitness in Acinetobacter baumannii has not yet been studied. Comparisons of molecular characteristics were performed between 32 multidrug-resistant A. baumannii isolates and 11 susceptible isolates. A soxR overexpression mutant was constructed, and its resistance phenotype was analyzed. The impact of SoxR on efflux pump gene expression was measured at the transcription level. The effect of SoxR on the growth and fitness of A. baumannii was analyzed using a growth rate assay and an in vitro competition assay. The frequency of the Gly39Ser mutation in soxR was higher in multidrug-resistant A. baumannii, whereas the soxS gene was absent in all strains analyzed. SoxR overexpression led to increased susceptibility to chloramphenicol (4-fold), tetracycline (2-fold), tigecycline (2-fold), ciprofloxacin (2-fold), amikacin (2-fold), and trimethoprim (2-fold), but it did not influence imipenem susceptibility. Decreased expression of abeS (3.8-fold), abeM (1.3-fold), adeJ (2.4-fold), and adeG (2.5-fold) were correlated with soxR overexpression (P < .05). However, the expression levels of adeB and craA showed no obvious difference in the soxR-overexpression mutant. Competitive growth test results showed that soxR overexpression led to a lower growth rate, which was associated with a significant fitness cost in vitro. These results reveal that the global regulator SoxR is a negative regulator of efflux pump gene expression, and contributes to antibiotic resistance and fitness in A. baumannii.
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