SynthesisMedicine2017
Worse clinical outcomes following percutaneous coronary intervention with a high SYNTAX score: A systematic review and meta-analysis.
Synthesis in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparing CABG and PCI across the globe based on current regional registry evidence.Scientific reports · 2022Pooled it
- Use of the SYNTAX Score II to predict mortality in interventional cardiology: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Pooled it
- A nomogram model for predicting intramyocardial hemorrhage post-PCI based on SYNTAX score and clinical features.BMC cardiovascular disorders · 2024Trial
- Short-Term Prognostic Value of the Culprit-SYNTAX Score in Patients with Acute Myocardial Infarction.Journal of cardiovascular development and disease · 2023Article
- AngioScore: An artificial intelligence tool to assess coronary artery lesions.Cardiology journal · 2023Article
- The association between SYNTAX score and long-term outcomes in patients with unstable angina pectoris: a single-centre retrospective study.BMC cardiovascular disorders · 2022Article
- Effect of Tai Chi on cardiac function in patients with myocardial infarction: A protocol for a randomized controlled trial.Medicine · 2021Article
- Syntax Score I and II for Predicting Carotid Artery Stenosis in Patients with Multivessel Coronary Artery Disease: A Propensity Score Matching Analysis.Brazilian journal of cardiovascular surgery · 2019Article
- Clinical outcome comparison of percutaneous coronary intervention and bypass surgery in diabetic patients with coronary artery disease: a meta-analysis of randomized controlled trials and observational studies.Diabetology & metabolic syndrome · 2019Article
- Plasma neutrophil gelatinase-associated lipocalin levels are associated with the presence and severity of coronary heart disease.PloS one · 2019Article
- Impact of right coronary dominance on triple-vessel coronary artery disease: A cross-sectional study.Medicine · 2018Article
- Early (≤ 30 Days), Late (31-360 Days) and Very Late (> 360 Days) Stent Thrombosis in Patients with Insulin-Treated versus Non-Insulin-Treated Type 2 Diabetes Mellitus: A Meta-Analysis.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe synergy between percutaneous coronary intervention (PCI) with TAXUS and Cardiac Surgery (SYNTAX) score is an angiographic tool which is used to determine the complexity of coronary artery disease (CAD). We aimed to compare PCI versus coronary artery bypass surgery (CABG) in patients with a high SYNTAX score in order to confirm with evidence whether the former is really association with worse clinical outcomes.
methodsThe National database of medical research articles (MEDLINE/PubMed), EMBASE database, and the Cochrane library were searched for publications comparing PCI versus CABG in patients with a high SYNTAX score, respectively. Death, myocardial infarction (MI), stroke, repeated revascularization, and a combined outcome death/stroke/MI were considered as the clinical endpoints. RevMan software was used to analyze the data, whereby odds ratios (OR) with 95% confidence intervals (CI) were used as the statistical parameters.
resultsA total number of 1074 patients were included (455 patients with a high SYNTAX score were classified in the PCI group and 619 other patients with a high SYNTAX score were classified in the CABG group). A SYNTAX score cut-off value of ≥33 was considered relevant. Compared with CABG, mortality was significantly higher with a high SYNTAX score following PCI with OR: 1.79, 95% CI: 1.18 to 2.70; P = .006, I = 0%. The combined outcome death/stroke/MI was also significantly higher following PCI with a high SYNTAX score, with OR: 1.69, 95% CI: 1.24 to 2.30; P = .0009, I = 0%. In addition, PCI was also associated with significantly higher MI and repeated revascularization when compared with CABG, with OR: 3.72, 95% CI: 1.75 to 7.89; P = .0006, I = 0% and OR: 4.33, 95% CI: 1.71 to 10.94; P = .002, I = 77%, respectively. However, stroke was not significantly different.
conclusionsCompared with CABG, worse clinical outcomes were observed following PCI in patients with a high SYNTAX score, confirming with evidence, published clinical literatures. Therefore, CABG should be recommended to CAD patients who have been allotted a high SYNTAX score.
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