The efficiency and safety of dexamethasone for pain control in total joint arthroplasty: A meta-analysis of randomized controlled trials.

backgroundThis meta-analysis aimed to evaluate the efficiency and safety of dexamethasone administration in total knee and hip arthroplasties.

methodsTwo researchers search the relevant studies independently including Embase (1980-017.04), PubMed (1966-017.04), ScienceDirect (1985-017.04), Web of Science (1950-2017.03), and Cochrane Library for potential relevant studies. After testing for heterogeneity between studies, data were aggregated for random-effects models when necessary. The results of dichotomous outcomes were expressed as risk difference (RD) with a 95% confidence intervals (CIs). For continuous various outcomes, mean difference (MD) or standard mean difference (SMD) with a 95% confidence intervals (CIs) was applied for assessment. Meta-analysis was performed using Stata 11.0 software.

resultsFour randomized controlled trials (RCTs) including 361 patients met the inclusion criteria. The present meta-analysis indicated that there were significant differences between groups in terms of visual analogue scale (VAS) score at 12 hours (SMD = -0.579, 95% CI: -0.780 to -0.357, P = .000), 24 hours (SMD = -0.820, 95% CI: -1.036 to -0.604, P = .000), and 48 hours (SMD = -0.661, 95% CI: -1.149 to -0.172, P = .008). Dexamethasone was associated with a lower opioid consumption at 12 hours (SMD = -0.245, 95% CI: -0.465 to -0.025, P = .029), 24 hours (SMD = -0.285, 95% CI: -0.505 to -0.064, P = .011), and 48 hours (SMD = -0.989, 95% CI: -1.710 to -0.267, P = .007).

conclusionDexamethasone could significantly reduce postoperative pain scores and opioid consumption within the 1st 48 hours following total joint arthroplasty (TJA). The overall evidence quality was moderate to low, further high-quality RCTs are needed to identify the optimal dose of dexamethasone for reducing pain after TJA.