Evidence map›Paper›PMID 28614011›Full record

SynthesisViral immunology2017

Structural Basis for CD4+ T Cell Epitope Dominance in Arbo-Flavivirus Envelope Proteins: A Meta-Analysis.

Samuel J Landry, Daniel L Moss, Da Cui, Ryan P Ferrie, Mitchell L Fullerton, Evan A Wells, Lu Yang, Nini Zhou, Thomas Dougherty, Ramgopal R Mettu

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Viral immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. CD4Vaccines · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. CD4 T cell responses to flaviviruses.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2018
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samuel J Landry1 Department of Biochemistry, Tulane University School of Medicine , New Orleans, Louisiana.
Daniel L Moss1 Department of Biochemistry, Tulane University School of Medicine , New Orleans, Louisiana.
Da Cui1 Department of Biochemistry, Tulane University School of Medicine , New Orleans, Louisiana.
Ryan P Ferrie1 Department of Biochemistry, Tulane University School of Medicine , New Orleans, Louisiana.
Mitchell L Fullerton1 Department of Biochemistry, Tulane University School of Medicine , New Orleans, Louisiana.
Evan A Wells1 Department of Biochemistry, Tulane University School of Medicine , New Orleans, Louisiana.
Lu Yang1 Department of Biochemistry, Tulane University School of Medicine , New Orleans, Louisiana.
Nini Zhou1 Department of Biochemistry, Tulane University School of Medicine , New Orleans, Louisiana.
Thomas Dougherty1 Department of Biochemistry, Tulane University School of Medicine , New Orleans, Louisiana.
Ramgopal R Mettu2 Department of Computer Science, Tulane University , New Orleans, Louisiana.

Funding

Antigen Structure-Based Supervised Learning for CD4+ T-cell Epitope PredictionR21AI122199 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI METTU, RAMGOPAL · 2016 to 2017
$414k
NIAID NIH HHS R21 AI122199
6 · The paper itself

Abstract

A meta-analysis of CD4+ T cell epitope maps reveals clusters and gaps in envelope-protein (E protein) immunogenicity that can be explained by the likelihood of epitope processing, as determined by E protein three-dimensional structures. Differential processing may be at least partially responsible for variations in disease severity among arbo-flaviruses and points to structural features that modulate protection from disease.

Indexed as

Models, ImmunologicalAnimalsCD4-Positive T-LymphocytesDatabases, ProteinEpitope MappingEpitopes, T-LymphocyteFlavivirusHistocompatibility Antigens Class IIHumansImmunodominant EpitopesProtein BindingProtein ConformationStructure-Activity RelationshipViral Envelope ProteinsEpitopes, T-LymphocyteHistocompatibility Antigens Class IIImmunodominant EpitopesViral Envelope Proteinsantigen processingclass II MHC proteinhelper T cell

Identifiers

PMID28614011
PMCPMC5610399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.