Evidence map›Paper›PMID 28613990›Full record

ArticleRadiation research2017

Different Sequences of Fractionated Low-Dose Proton and Single Iron-Radiation-Induced Divergent Biological Responses in the Heart.

Sharath P Sasi, Xinhua Yan, Marian Zuriaga-Herrero, Hannah Gee, Juyong Lee, Raman Mehrzad, Jin Song, Jillian Onufrak, James Morgan, Heiko Enderling and 3 more

Abstract read
In one paragraph

Article in Radiation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025
    Pooled it
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  14. The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sharath P Sasia   Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts.
Xinhua Yana   Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts.
Marian Zuriaga-Herrerof   Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts.
Hannah Geea   Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts.
Juyong Leec   Calhoun Cardiology Center, University of Connecticut Health Center, Farmington, Connecticut.
Raman Mehrzadd   Steward Carney Hospital, Dorchester, Massachusetts.
Jin Songa   Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts.
Jillian Onufraka   Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts.
James Morganb   Tufts University School of Medicine, Boston, Massachusetts.
Heiko Enderlinge   Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Kenneth Walshf   Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts.
Raj Kishore7   Center for Translational Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania.
David A Goukassiana   Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts.

Funding

TNF mRNA stability and restenosisR01HL091983 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2009 to 2022
$5.3M
Neuregulin1 Alleviation of the "On-Target" Cardiotoxicity Caused by Inhibition ofR21HL106098 · NHLBI · GENESYS RESEARCH INSTITUTE, INC. · PI YAN, XINHUA · 2012 to 2013
$450k
NHLBI NIH HHS R01 HL091983NHLBI NIH HHS R21 HL106098
6 · The paper itself

Abstract

Deep-space travel presents risks of exposure to ionizing radiation composed of a spectrum of low-fluence protons (

Indexed as

Dose Fractionation, RadiationAnimalsCosmic RadiationDose-Response Relationship, RadiationHeartIronMaleMiceMice, Inbred C57BLMyocardial InfarctionProtonsIronProtons

Identifiers

PMID28613990
PMCPMC6555403

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.