Evidence map›Paper›PMID 28613884›Full record

ArticleBiochemistry2017

Carbohydrate-Polypeptide Contacts in the Antibody Receptor CD16A Identified through Solution NMR Spectroscopy.

Ganesh P Subedi, Daniel J Falconer, Adam W Barb

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Chemical Shift Analysis of Oligosaccharides.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Method for Identifying Galectin Ligands on Lymphocyte Membrane Glycoproteins.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Glycan structures and their interactions with proteins. A NMR view.Current opinion in structural biology · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ganesh P SubediRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University , 2437 Pammel Drive, Molecular Biology Building, Room 4210, Ames, Iowa 50011, United States.
Daniel J FalconerRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University , 2437 Pammel Drive, Molecular Biology Building, Room 4210, Ames, Iowa 50011, United States.
Adam W BarbRoy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University , 2437 Pammel Drive, Molecular Biology Building, Room 4210, Ames, Iowa 50011, United States.ORCID 0000-0003-3290-8649
Iowa State University · US

Funding

Mechanism and engineering of IgG-based monoclonal antibody/receptor interactionsR01GM115489 · NIGMS · UNIVERSITY OF GEORGIA · PI BARB, ADAM WESLEY · 2015 to 2019
$1.4M
NIGMS NIH HHS R01 GM115489
6 · The paper itself

Abstract

Asparagine-linked carbohydrates (N-glycans) are common modifications of eukaryotic proteins that confer multiple properties, including the essential stabilization of therapeutic monoclonal antibodies. Here we present a rapid and efficient strategy for identifying N-glycans that contact polypeptide residues and apply the method to profile the five N-glycans attached to the human antibody receptor CD16A (Fc γ receptor IIIA). Human embryonic kidney 293S cells expressed CD16A with

Indexed as

Carbohydrate ConformationCarbohydratesHumansNuclear Magnetic Resonance, BiomolecularPeptide FragmentsPolysaccharidesProtein ConformationReceptors, IgGCarbohydratesFCGR3A protein, humanPeptide FragmentsPolysaccharidesReceptors, IgG

Identifiers

PMID28613884
PMCPMC5925738
OpenAlexW2625439015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.