ArticleACS chemical biology2017
Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.
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Article in ACS chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
What it found
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Exploring protein lipidation by mass spectrometry-based proteomics.Journal of biochemistry · 2024Review
- Methylglyoxal and Its Adducts: Induction, Repair, and Association with Disease.Chemical research in toxicology · 2022Review
- HIF1, HSF1, and NRF2: Oxidant-Responsive Trio Raising Cellular Defenses and Engaging Immune System.Chemical research in toxicology · 2022Review
- PUFA-DerivedACS chemical biology · 2022Article
- Function-guided proximity mapping unveils electrophilic-metabolite sensing by proteins not present in their canonical locales.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Staphylococcus aureus Peptide Methionine Sulfoxide Reductases Protect from Human Whole-Blood Killing.Infection and immunity · 2021Article
- A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications.Chemical reviews · 2021Review
- Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes.Cell chemical biology · 2020Article
- REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins.Methods in enzymology · 2020Article
- Article
- Regulation of stress signaling pathways by protein lipoxidation.Redox biology · 2019Review
- 2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct.Redox biology · 2019Article
- Post-Translational Modification of Proteins Mediated by Nitro-Fatty Acids in Plants: Nitroalkylation.Plants (Basel, Switzerland) · 2019Review
- Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles.Trends in biochemical sciences · 2019Review
- Cholesterol secosterol aldehyde adduction and aggregation of Cu,Zn-superoxide dismutase: Potential implications in ALS.Redox biology · 2018Article
- Unbiased Identification of Proteins Covalently Modified by Complex Mixtures of Peroxidized Lipids Using a Combination of Electrophoretic Mobility Band Shift with Mass Spectrometry.Antioxidants (Basel, Switzerland) · 2018Article
- Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies.Redox biology · 2018Review
- Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells.Molecular & cellular proteomics : MCP · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
William N BeaversA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.ORCID 0000-0002-0285-7775
Kristie L RoseA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
James J GalliganA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.ORCID 0000-0002-5612-0680
Michelle M MitchenerA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Carol A RouzerA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Keri A TallmanA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Connor R LambersonA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Xiaojing WangA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Salisha HillA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Pavlina T IvanovaA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
H Alex BrownA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Bing ZhangA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Ned A PorterA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.
Lawrence J MarnettA.B. Hancock Memorial Laboratory for Cancer Research, Departments of Chemistry, ‡Biochemistry, §Pharmacology, ∥Biomedical Informatics, ⊥Vanderbilt Mass Spectrometry Research Center, Vanderbilt Institute for Chemical Biology, Vanderbilt Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University , Nashville, Tennessee 37232, United States.ORCID 0000-0002-7834-6285
Vanderbilt University · US
Funding
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MChemistry and Biology of Malondialdehyde DNA AdductsR37CA087819 · NCI · VANDERBILT UNIVERSITY · PI MARNETT, LAWRENCE J. · 2005 to 2014
$4.2MCHEMISTRY AND BIOLOGY OF MALONDIALDEHYDE DNA ADDUCTSR01CA087819 · NCI · VANDERBILT UNIVERSITY · PI MARNETT, LAWRENCE J. · 2000 to 2020
$4.0MLTQ Orbitrap XL ETD Hybrid FT High Resolution Mass SpectrometerS10RR027714 · NCRR · VANDERBILT UNIVERSITY · PI HACHEY, DAVID L · 2010 to 2010
$479kNCATS NIH HHS UL1 TR000445NCI NIH HHS R01 CA087819NCI NIH HHS R37 CA087819NCRR NIH HHS S10 RR027714
Abstract
Determining the impact of lipid electrophile-mediated protein damage that occurs during oxidative stress requires a comprehensive analysis of electrophile targets adducted under pathophysiological conditions. Incorporation of ω-alkynyl linoleic acid into the phospholipids of macrophages prior to activation by Kdo
Indexed as
Lipid PeroxidationProtein Processing, Post-TranslationalAnimalsLipidsMitochondriaMolecular StructureProteinsSignal TransductionLipidsProteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.