Evidence map›Paper›PMID 28613276›Full record

SynthesisNature communications2017

Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Ilja M Nolte, M Loretto Munoz, Vinicius Tragante, Azmeraw T Amare, Rick Jansen, Ahmad Vaez, Benedikt von der Heyde, Christy L Avery, Joshua C Bis, Bram Dierckx and 154 more

Erratum issuedOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 4 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 161 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Article
  6. Are There Causal Associations Between Obsessive-Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic Correlation and Bi-Directional Mendelian Randomization Study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026
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  19. Sex-specific genetic architecture of late-life memory performance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

164 authors at 20 institutions in 21 countries.

Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.ORCID 0000-0001-5047-4077
M Loretto MunozDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Vinicius TraganteDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.
Azmeraw T AmareDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.ORCID 0000-0002-7940-0335
Rick JansenDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.ORCID 0000-0002-3333-6737
Ahmad VaezDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.ORCID 0000-0001-9048-3795
Benedikt von der HeydeDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
Christy L AveryDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
Bram DierckxDepartment of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
Jenny van DongenDepartment of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
Stephanie M GogartenDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
Philippe GoyetteMontreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
Jussi HernesniemiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Ville HuikariCenter for Life Course Health Research, University of Oulu, Oulu 90014, Finland.
Shih-Jen HwangFramingham Heart Study, Framingham, Massachusetts 01702, USA.
Deepali JajuDepartment of Clinical Physiology, Sultan Qaboos University Hospital, Muscat-Al Khoudh 123, Sultanate of Oman.
Kathleen F KerrDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
Alexander KluttigInstitute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale) 06097, Germany.
Bouwe P KrijtheDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
Jitender KumarDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
Sander W van der LaanLaboratory of Experimental Cardiology, Department of Heart and Lung, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.ORCID 0000-0001-6888-1404
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Adam X MaihoferDepartment of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
Arpi MinassianDepartment of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.ORCID 0000-0001-8450-3518
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
Michel NivardDepartment of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.ORCID 0000-0003-2015-1888
Erika SalviDepartment of Health Sciences, University of Milano, Milano 20122, Italy.ORCID 0000-0002-2724-2291
James D StewartDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Julian F ThayerDepartment of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, Ohio 43210, USA.
Niek VerweijDepartment of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.ORCID 0000-0002-4303-7685
Andrew WongMRC Unit for Lifelong Health and Ageing, University College London, 33 Bedford Place, London WC1B 5JU, UK.ORCID 0000-0003-2079-4779
Delilah ZabanehInstitute of Psychiatry, Psychology &Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK.
Mohammad H ZafarmandDepartment of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Abdel AbdellaouiDepartment of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
Sulayma AlbarwaniDepartment of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat Al-Khoudh 123, Sultanate of Oman.
Christine AlbertBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
Foram AsharMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Juha AuvinenCenter for Life Course Health Research, University of Oulu, Oulu 90014, Finland.
Tomas AxelssonDepartment of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75237, Sweden.
Dewleen G BakerCenter for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, California 92161, USA.
Paul I W de BakkerDepartment of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
Matteo BarcellaDepartment of Health Sciences, University of Milano, Milano 20122, Italy.
Riad BayoumiCollege of Medicine, Mohammed Bin Rashid University, PO Box 505055, Dubai Healthcare City, United Arab Emirates.
Rob J BieringaDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Dorret BoomsmaDepartment of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
Gabrielle BoucherMontreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
Annie R BrittonDepartment of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
Ingrid ChristophersenCardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Andrea DietrichDepartment of Child- and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
George B EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Patrick T EllinorProgram in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02114, USA.ORCID 0000-0002-2067-0533
Markku EskolaDepartment of Cardiology, Heart Hospital, Tampere University Hospital, Tampere 33521, Finland.
Janine F FelixDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
John S FlorasUniversity Health Network and Mount Sinai Hospital Division of Cardiology, Department of Medicine, University of Toronto, Ontario, Canada M5S.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
Peter FribergDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
Maaike G J GademanDepartment of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Mark A GeyerDepartment of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala 75237, Sweden.
Catharina A HartmanInterdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Daiane HemerichDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
Jouke-Jan HottengaDepartment of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
Heikki HuikuriResearch Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland.
Nina Hutri-KähönenDepartment of Pediatrics, Tampere University Hospital, Tampere 33521, Finland.
Xavier JouvenINSERM U970, Paris Descartes University, Paris 75006, France.
Juhani JunttilaResearch Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland.
Markus JuonalaDepartment of Medicine, University of Turku, Turku 20520, Finland.
Antti M KiviniemiResearch Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu 90220, Finland.ORCID 0000-0002-1160-493X
Jan A KorsDepartment of Medical Informatics, Erasmus Medical Center, Rotterdam 3015 CE, The Netherlands.
Meena KumariDepartment of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
Tatiana KuznetsovaStudies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium.
Cathy C LaurieDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
Joop D LefrandtDepartment of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Yong LiDivision of Genetic Epidemiology, Institute for Medical Biometry and Statistics, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany.
Yun LiDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Duanping LiaoDivision of Epidemiology, Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA.
Marian C LimacherDivision of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida 32611, USA.
Henry J LinInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Cecilia M LindgrenLi Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford, Oxford OX3 7BN, UK.
Steven A LubitzProgram in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02114, USA.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Barbara McKnightCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
Henriette Meyer Zu SchwabedissenBiopharmacy, Department Pharmaceutical Sciences, University of Basel, Basel CH-4056, Switzerland.
Yuri MilaneschiDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.
Nina MononenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
Gerjan NavisDepartment of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Melanie NeijtsDepartment of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
Kjell NikusDepartment of Cardiology, Heart Hospital, Tampere University Hospital, Tampere 33521, Finland.
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Daniel T O'ConnorDepartment of Medicine, University of California, San Diego, San Diego, California 92093, USA.
Johan OrmelInterdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Siegfried PerzInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
Annette PetersDZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich 80336, Germany.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.
Victoria B RisbroughDepartment of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
Moritz F SinnerDepartment of Medicine, University Hospital Munich, Ludwig-Maximilians-University, Munich 80539, Germany.
David SiscovickThe New York Academy of Medicine, New York, New York 10029, USA.
Johannes H SmitDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.
Nicholas L SmithGroup Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA.
Elsayed Z SolimanEpidemiological Cardiology Research Center (EPICARE), Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.ORCID 0000-0001-5632-8150
Nona SotoodehniaCardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington 98101, USA.
Jan A StaessenStudies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven 3000, Belgium.
Phyllis K SteinHeart Rate Variability Lab, Washington University School of Medicine, St Louis, Missouri 63108, USA.
Adrienne M StilpDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
Katarzyna Stolarz-SkrzypekFirst Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Cracow 31-008, Poland.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
Johan SundströmDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.
Cees A SwenneDepartment of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Ann-Christine SyvänenDepartment of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75237, Sweden.
Jean-Claude TardifMontreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90509, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.ORCID 0000-0002-8309-094X
Timothy A ThorntonDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
Lesley E TinkerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
André G UitterlindenDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
Jessica van SettenDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.ORCID 0000-0002-4934-7510
Andreas VossInstitute of Innovative Health Technologies-IGHT Jena Ernst-Abbe-Hochschule Jena, Jena 07745, Germany.
Melanie WaldenbergerInstitute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
Kirk C WilhelmsenDepartments of Genetics and Neurology University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Gonneke WillemsenDepartment of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
Quenna WongDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
Zhu-Ming ZhangEpidemiological Cardiology Research Center (EPICARE), Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Daniele CusiInstitute of Biomedical Technologies, CNR-Italian National Research Council, Milan 20090, Italy.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Halina K GreiserGerman Cancer Research Centre, Division of Cancer Epidemiology, Heidelberg 69210, Germany.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Mohammad HassanDepartment of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat Al-Khoudh 123, Sultanate of Oman.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
Marjo-Riitta JärvelinCenter for Life Course Health Research, University of Oulu, Oulu 90014, Finland.
Stefan KääbDepartment of Medicine, University Hospital Munich, Ludwig-Maximilians-University, Munich 80539, Germany.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.ORCID 0000-0002-4699-5627
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Diana KuhMRC Unit for Lifelong Health and Ageing, University College London, 33 Bedford Place, London WC1B 5JU, UK.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.
Caroline M NievergeltDepartment of Psychiatry, University of California, San Diego, San Diego, California 92093, USA.
Chris J O'DonnellFramingham Heart Study, Framingham, Massachusetts 01702, USA.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Brenda PenninxDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest, Amsterdam 1081 BT, The Netherlands.
Alexander P ReinerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Harriëtte RieseInterdisciplinary Center Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Arie M van RoonDepartment of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
John D RiouxMontreal Heart Institute, Montreal, Quebec, Canada H1T 1C8.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90509, USA.
Tamar SoferDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, Washington 98195, USA.
Bruno H StrickerDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, PO Box 2060, Rotterdam 3000 CB, The Netherlands.
Henning TiemeierDepartment of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry, PO Box 2060, Rotterdam 3000 CB, The Netherlands.ORCID 0000-0002-4395-1397
Tanja G M VrijkotteDepartment of Public Health, Academic Medical Center (AMC), University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.
Folkert W AsselbergsDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584CX, The Netherlands.ORCID 0000-0002-1692-8669
Bianca J J M BrundelDepartment of Physiology, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1118, Amsterdam 1081 HV, The Netherlands.
Susan R HeckbertCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98104, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Marcel den HoedDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75237, Sweden.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.
Eco J C de GeusDepartment of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.
University Medical Center Groningen · NLUniversity of Washington · USUppsala University · SEAmsterdam Public Health · NLUniversity of North Carolina at Chapel Hill · USUniversity of San Diego · USErasmus MC · NLOulu University Hospital · FIAmsterdam Neuroscience · NLHeidelberg University · DEHelmholtz Zentrum München · DEMontreal Heart Institute · CATampere University · FIAmsterdam UMC Location University of Amsterdam · NLBroad Institute · USCentre for Human Genetics · GBNational Institutes of Health · USTampere University Hospital · FIThe Lundquist Institute · USAmerican Academy of Child and Adolescent Psychiatry · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Statistical Methods for X-Chromosome Genetic DataP01GM099568 · NIGMS · UNIVERSITY OF WASHINGTON · PI THORNTON, TIMOTHY ALVIN · 2012 to 2016
$7.3M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Genomics of Cardiac Electrical Activity and ArrhythmiaR01HL116747 · NHLBI · UNIVERSITY OF WASHINGTON · PI ARKING, DAN E, SOTOODEHNIA, NONA · 2013 to 2016
$2.8M
Atrial Fibrillation: Bridging genetic discovery and clinical associationsK23HL114724 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LUBITZ, STEVEN A · 2013 to 2017
$893k
FHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600k
Role of COMTval158met in PTSD risk and treatment responseI01BX002558 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI RISBROUGH, VICTORIA B · 2015 to 2018
–
BLRD VA I01 BX002558Medical Research Council MC_UU_12019/1NCATS NIH HHS UL1 TR000124NHLBI NIH HHS K23 HL114724NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL116747NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL130114NICHD NIH HHS P2C HD050924NIDDK NIH HHS P30 DK063491NIGMS NIH HHS P01 GM099568NIH HHS S10 OD020069
6 · The paper itself

Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74<r

Indexed as

Heart RateBlood PressureCohort StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHeart DiseasesHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMuscle ProteinsPolymorphism, Single NucleotidePotassium ChannelsQuantitative Trait LociRGS ProteinsRisk FactorsWhite PeopleHCN4 protein, humanHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMuscle ProteinsPotassium ChannelsRGS6 protein, humanRGS Proteins

Identifiers

PMID28613276
PMCPMC5474732
OpenAlexW2625940930

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.