Evidence map›Paper›PMID 28613249›Full record

Trial reportInternational journal of molecular sciences2017

Hypoxia Inducible Factor-2 Alpha and Prolinhydroxylase 2 Polymorphisms in Patients with Acute Respiratory Distress Syndrome (ARDS).

Annika Dötsch, Lewin Eisele, Miriam Rabeling, Katharina Rump, Kai Walstein, Alexandra Bick, Linda Cox, Andrea Engler, Hagen S Bachmann, Karl-Heinz Jöckel and 3 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  5. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Annika DötschKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. annika.doetsch@uk-essen.de.
Lewin EiseleInstitut für Medizinische Informatik, Biometrie und Epidemiologie, D-45122 Essen, Germany. lewin.eisele@uk-essen.de.
Miriam RabelingKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. MiriamRabeling@t-online.de.
Katharina RumpKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. katharina.k.rump@rub.de.
Kai WalsteinKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. kai.walstein@gmail.com.
Alexandra BickKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. alexandra.bick@uk-essen.de.
Linda CoxKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. linda.cox@uk-essen.de.
Andrea EnglerKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. andrea.engler@uk-essen.de.
Hagen S BachmannInstitut für Pharmakogenetik, Universitätsklinikum Essen and Universität Duisburg-Essen, D-45122 Essen, Germany. hagen.bachmann@uk-essen.de.
Karl-Heinz JöckelInstitut für Medizinische Informatik, Biometrie und Epidemiologie, D-45122 Essen, Germany.
Michael AdamzikKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. michael.adamzik@kk-bochum.de.
Jürgen PetersKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. juergen.peters@uni-duisburg-essen.de.
Simon T SchäferKlinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstraße 55, D-45122 Essen, Germany. simon.schaefer@uk-essen.de.
Essen University Hospital · DEInstitut für Medizinische Informatik, Biometrie und Epidemiologie · DELudwig-Maximilians-Universität München · DEUniversity of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia-inducible-factor-2α (HIF-2α) and HIF-2 degrading prolyl-hydroxylases (PHD) are key regulators of adaptive hypoxic responses i.e., in acute respiratory distress syndrome (ARDS). Specifically, functionally active genetic variants of

Indexed as

Polymorphism, Single NucleotideAdultAgedBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1FemaleGenotypeHumansHypoxia-Inducible Factor-Proline DioxygenasesKaplan-Meier EstimateMaleMiddle AgedProportional Hazards ModelsProspective StudiesRespiratory Distress SyndromeBasic Helix-Loop-Helix ProteinsEGLN1 protein, humanEndothelial PAS Domain-Containing Protein 1Hypoxia-Inducible Factor-Proline Dioxygenasesacute respiratory distress syndromegenetic variantshypoxia inducible factorspolymorphismprolylhydroxylases

Identifiers

PMID28613249
PMCPMC5486088
OpenAlexW2626066978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.