ArticleeLife2017
Physical limits of flow sensing in the left-right organizer.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Dynamic forces drive cell and organ morphology changes during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Breaking Left-Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia.Cells · 2024Review
- Emerging mechanistic understanding of cilia function in cellular signalling.Nature reviews. Molecular cell biology · 2024Review
- R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient.Nature communications · 2024Article
- Emerging principles of primary cilia dynamics in controlling tissue organization and function.The EMBO journal · 2023Review
- Fluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breaking.eLife · 2023Article
- Polycystin Channel Complexes.Annual review of physiology · 2023Review
- Cilia function as calcium-mediated mechanosensors that instruct left-right asymmetry.Science (New York, N.Y.) · 2023Article
- Structures and functions of cilia during vertebrate embryo development.Molecular reproduction and development · 2022Review
- Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo.Bioengineering (Basel, Switzerland) · 2022Article
- Understanding laterality disorders and the left-right organizer: Insights from zebrafish.Frontiers in cell and developmental biology · 2022Review
- Fluid Mechanics of Mosaic Ciliated Tissues.Physical review letters · 2021Article
- Article
- CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images.The European physical journal. E, Soft matter · 2021Article
- Chemosensing versus mechanosensing in nodal and Kupffer's vesicle cilia and in other left-right organizer organs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Simulations of particle tracking in the oligociliated mouse node and implications for left-right symmetry-breaking mechanics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Article
- Molecular and cellular basis of left-right asymmetry in vertebrates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020Review
- Diversity of left-right symmetry breaking strategy in animals.F1000Research · 2020Review
- Three-dimensional microscopy and image analysis methodology for mapping and quantification of nuclear positions in tissues with approximate cylindrical geometry.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluid flows generated by motile cilia are guiding the establishment of the left-right asymmetry of the body in the vertebrate left-right organizer. Competing hypotheses have been proposed: the direction of flow is sensed either through mechanosensation, or via the detection of chemical signals transported in the flow. We investigated the physical limits of flow detection to clarify which mechanisms could be reliably used for symmetry breaking. We integrated parameters describing cilia distribution and orientation obtained in vivo in zebrafish into a multiscale physical study of flow generation and detection. Our results show that the number of immotile cilia is too small to ensure robust left and right determination by mechanosensing, given the large spatial variability of the flow. However, motile cilia could sense their own motion by a yet unknown mechanism. Finally, transport of chemical signals by the flow can provide a simple and reliable mechanism of asymmetry establishment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.