Evidence map›Paper›PMID 28613146›Full record

ArticleThe Journal of general virology2017

Revisiting the genotyping scheme for varicella-zoster viruses based on whole-genome comparisons.

Nancy J Jensen, Pierre Rivailler, Hung Fu Tseng, Mark L Quinlivan, Kay Radford, Jennifer Folster, Rafael Harpaz, Philip LaRussa, Steven Jacobsen, D Scott Schmid

Abstract read
In one paragraph

Article in The Journal of general virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nancy J JensenCenters for Disease Control and Prevention, National Center for Immunizations and Respiratory Diseases, Division of Viral Diseases, Atlanta, GA, USA.
Pierre RivaillerCenters for Disease Control and Prevention, National Center for Immunizations and Respiratory Diseases, Division of Viral Diseases, Atlanta, GA, USA.
Hung Fu TsengKaiser Permanente of Southern California, Department of Research and Evaluation, Pasadena, CA, USA.
Mark L QuinlivanCenters for Disease Control and Prevention, National Center for Immunizations and Respiratory Diseases, Division of Viral Diseases, Atlanta, GA, USA.
Kay RadfordCenters for Disease Control and Prevention, National Center for Immunizations and Respiratory Diseases, Division of Viral Diseases, Atlanta, GA, USA.
Jennifer FolsterCenters for Disease Control and Prevention, National Center for Immunizations and Respiratory Diseases, Division of Viral Diseases, Atlanta, GA, USA.
Rafael HarpazCenters for Disease Control and Prevention, National Center for Immunizations and Respiratory Diseases, Division of Viral Diseases, Atlanta, GA, USA.
Philip LaRussaDepartment of Pediatrics, Columbia University, College of Physicians and Surgeons,, New York, NY, USA.
Steven JacobsenKaiser Permanente of Southern California, Department of Research and Evaluation, Pasadena, CA, USA.
D Scott SchmidCenters for Disease Control and Prevention, National Center for Immunizations and Respiratory Diseases, Division of Viral Diseases, Atlanta, GA, USA.

Funding

Zoster Vaccine and Risk Factors of Zoster and Post-Herpetic NeuralgiaR01AI089930 · NIAID · KAISER FOUNDATION RESEARCH INSTITUTE · PI TSENG, HUNGFU · 2011 to 2015
$3.0M
NIAID NIH HHS R01 AI089930
6 · The paper itself

Abstract

We report whole-genome sequences (WGSs) for four varicella-zoster virus (VZV) samples from a shingles study conducted by Kaiser Permanente of Southern California. Comparative genomics and phylogenetic analysis of all published VZV WGSs revealed that strain KY037798 is in clade IX, which shall henceforth be designated clade 9. Previously published single nucleotide polymorphisms (SNP)-based genotyping schemes fail to discriminate between clades 6 and VIII and employ positions that are not clade-specific. We provide an updated list of clade-specific positions that supersedes the list determined at the 2008 VZV nomenclature meeting. Finally, we propose a new targeted genotyping scheme that will discriminate the circulating VZV clades with at least a twofold redundancy. Genotyping strategies using a limited set of targeted SNPs will continue to provide an efficient 'first pass' method for VZV strain surveillance as vaccination programmes for varicella and zoster influence the dynamics of VZV transmission.

Indexed as

Genetic VariationGenotypePhylogenyCaliforniaGenome, ViralGenomicsGenotyping TechniquesHerpesvirus 3, HumanHerpes ZosterHumansPolymorphism, Single NucleotideSequence Analysis, DNA

Identifiers

PMID28613146
PMCPMC5721928

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.