Evidence map›Paper›PMID 28612953›Full record

ReviewThe European journal of neuroscience2018

Eye movements, sensorimotor adaptation and cerebellar-dependent learning in autism: toward potential biomarkers and subphenotypes.

Edward G Freedman, John J Foxe

Open access · greenAbstract readReview
In one paragraph

Review in The European journal of neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Atypical visual motion prediction abilities in autism spectrum disorder.Clinical psychological science : a journal of the Association for Psychological Science · 2021
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Early-life stress induces motor coordination dysfunction in adult mice.The journal of physiological sciences : JPS · 2018
    Article
  13. Article
  14. Review
  15. Neural Correlates of Sensory Abnormalities Across Developmental Disabilities.International review of research in developmental disabilities · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Edward G FreedmanDepartment of Neuroscience, The Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.ORCID 0000-0001-8570-6325
John J FoxeDepartment of Neuroscience, The Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
University of Rochester · US

Funding

Spatial Interaction of Otolith mediated Collic ReflexesP01NS048328 · NINDS · UNIVERSITY OF ROCHESTER · PI SCHIEBER, MARC H · 2005 to 2010
$6.4M
Neurophysiology of Multisensory IntegrationR01MH065350 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI FOXE, JOHN J · 2003 to 2007
$1.4M
NIMH NIH HHS R01 MH065350NINDS NIH HHS P01 NS048328
6 · The paper itself

Abstract

Because of the wide range of symptoms expressed in individuals with autism spectrum disorder (ASD) and their idiosyncratic severity, it is unlikely that a single remedial approach will be universally effective. Resolution of this dilemma requires identifying subgroups within the autism spectrum, based on symptom set and severity, on an underlying neuro-structural difference, and on specific behavioral dysfunction. This will provide critical insight into the disorder and may lead to better diagnoses, and more targeted remediation in these subphenotypes of people with ASD. In this review, we discuss findings that appear to link the structure of the cerebellar vermis and plasticity of the saccadic eye-movement system in people with an autism spectrum disorder (ASD). Differences in cerebellar vermis structure in ASD could critically impact visuo-sensorimotor development in early infancy, which may in turn manifest as the visual orienting, communication and social interaction differences often seen in this population. It may be possible to distinguish a subpopulation of children with vermal hypoplasia, to establish whether this group manifests more severe deficits in visual orienting and in adaptation to persistent visual errors, and to establish whether this putative subphenotype of ASD is associated with a specific and distinct clinical symptom profile.

Indexed as

Adaptation, PhysiologicalAutism Spectrum DisorderBiomarkersCerebellar VermisEye MovementsHumansPhenotypeVisual PerceptionBiomarkersadaptationautismcerebellumsaccades

Identifiers

PMID28612953
PMCPMC11800192
OpenAlexW2735239349

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.