ArticleMicrobiologyOpen2017
Functional analyses of the versicolorin B synthase gene in Aspergillus flavus.
Article in MicrobiologyOpen, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Pyruvate decarboxylase and its lysine succinylation contribute to the development and metabolite biosynthesis in pathogenic fungusMycology · 2026Article
- Whole Genome Sequence ofFrontiers in microbiology · 2021Article
- Quantitative Proteomic Analysis for High- and Low-Aflatoxin-YieldFrontiers in microbiology · 2021Article
- Heterologous pathway assembly reveals molecular steps of fungal terreic acid biosynthesis.Scientific reports · 2018Article
- Functional analyses of the versicolorin B synthase gene in Aspergillus flavus.MicrobiologyOpen · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aflatoxin is a toxic, carcinogenic mycotoxin primarily produced by Aspergillus parasiticus and Aspergillus flavus. Previous studies have predicted the existence of more than 20 genes in the gene cluster involved in aflatoxin biosynthesis. Among these genes, aflK encodes versicolorin B synthase, which converts versiconal to versicolorin B. Past research has investigated aflK in A. parasiticus, but few studies have characterized aflK in the animal, plant, and human pathogen A. flavus. To understand the potential role of aflK in A. flavus, its function was investigated here for the first time using gene replacement and gene complementation strategies. The aflK deletion-mutant ΔaflK exhibited a significant decrease in sclerotial production and aflatoxin biosynthesis compared with wild-type and the complementation strain ΔaflK::aflK. ΔaflK did not affect the ability of A. flavus to infect seeds, but downregulated aflatoxin production after seed infection. This is the first report of a relationship between aflK and sclerotial production in A. flavus, and our findings indicate that aflK regulates aflatoxin formation.
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