Evidence map›Paper›PMID 28612425›Full record

ReviewAmerican journal of hematology2017

Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management.

Maria Domenica Cappellini, Josep Comin-Colet, Angel de Francisco, Axel Dignass, Wolfram Doehner, Carolyn S Lam, Iain C Macdougall, Gerhard Rogler, Clara Camaschella, Rezan Kadir and 5 more

2 registry-linked trialsOpen access · hybridAbstract readReview
In one paragraph

Review in American journal of hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 213 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
213citing papers in PubMed, 4 pooled it
24.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03748043 phase4unknown statusnot on this mapstarted 2019, after this paper: background citation

the Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis

TypeinterventionalSponsorSouth Valley UniversityRan2019 to 2019Enrolled100ConditionsIron-deficiencyArmsLactoferrin, Ferric Hydroxide Polymaltose
NCT06951802 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Endometriosis and Pain Treatment by Intraoperative Administration of Low-dose Ketamine A Single-Centre, Prospective, Randomized, Controlled Trial

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2024 to 2026Enrolled118ConditionsEndometriosisArmsKetamine, Propofol
3 · Its place in the literature

Who cites it

213 citing papers in PubMed, 4 syntheses or guidelines pooled it, 494 citations in OpenAlex.

  1. Recent Advances in Research on Iron Metabolism, Ferritin, and Hepcidin.International journal of molecular sciences · 2026
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153 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 8 countries.

Maria Domenica CappelliniRare Diseases Centre, Department of Medicine and Medical Specialties, Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico, Milan, Italy.ORCID http://orcid.org/0000-0001-8676-6864
Josep Comin-ColetCommunity Heart Failure Program, Department of Cardiology, Bellvitge University Hospital, University of Barcelona and Biomedical Research Institut (IDIBELL), Hospitalet de Liobregat, Barcelona, Spain.
Angel de FranciscoDepartment of Nephrology, Valdecilla Universitario Hospital, University of Cantabria, Santander, Spain.
Axel DignassDepartment of Medicine I, Agaplesion Markus Hospital, Frankfurt, Germany.
Wolfram DoehnerCenter for Stroke Research CSB and Department of Cardiology, Virchow Campus, Charité Universitätsmedizin Berlin, Berlin, Germany.
Carolyn S LamDepartment of Cardiology, National Heart Centre Singapore and Duke-NUS Medical School, Singapore.
Iain C MacdougallDepartment of Renal Medicine, King's College Hospital, London, United Kingdom.
Gerhard RoglerDivision of Gastroenterology and Hepatology, University of Zurich, Zurich, Switzerland.
Clara CamaschellaDivision of Genetics and Cell Biology, San Raffaele Scientific Institute and Vita-Salute University, Milan, Italy.
Rezan KadirDepartment of Obstetrics & Gynaecology, Royal Free Foundation Hospital and University College Hospital, London, United Kingdom.
Nicholas J KassebaumInstitute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, DC.
Donat R SpahnInstitute of Anaesthesiology, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
Ali T TaherDepartment of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.ORCID http://orcid.org/0000-0001-8515-2238
Khaled M MusallamInternational Network of Hematology, London, United Kingdom.
IRON CORE Group
University of Zurich · CHAgaplesion Markus Hospital · DEAmerican University of Beirut Medical Center · LBBellvitge University Hospital · ESCharité - Universitätsmedizin Berlin · DEDuke-NUS Medical School · SGKing's College Hospital · GBSeattle Children's Hospital · USUniversidad de Cantabria · ESUniversity College Hospital · GBUniversity of Milan · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron deficiency, even in the absence of anemia, can be debilitating, and exacerbate any underlying chronic disease, leading to increased morbidity and mortality. Iron deficiency is frequently concomitant with chronic inflammatory disease; however, iron deficiency treatment is often overlooked, partially due to the heterogeneity among clinical practice guidelines. In the absence of consistent guidance across chronic heart failure, chronic kidney disease and inflammatory bowel disease, we provide practical recommendations for iron deficiency to treating physicians: definition, diagnosis, and disease-specific diagnostic algorithms. These recommendations should facilitate appropriate diagnosis and treatment of iron deficiency to improve quality of life and clinical outcomes.

Indexed as

Iron DeficienciesAdministration, OralAnemia, Iron-DeficiencyChronic DiseaseDiagnosis, DifferentialDisease ManagementHeart FailureHematinicsHumansInflammationInflammatory Bowel DiseasesInjections, IntravenousIronRenal Insufficiency, ChronicHematinicsIron

Identifiers

PMID28612425
PMCPMC5599965
OpenAlexW2737624346

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.