Evidence map›Paper›PMID 28612380›Full record

ArticleJournal of veterinary internal medicine2017

Breed, Coat Color, and Hair Length as Risk Factors for Hyperthyroidism in Cats.

V J Crossley, A Debnath, Y M Chang, R C Fowkes, J Elliott, H M Syme

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

V J CrossleyDepartment of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.ORCID http://orcid.org/0000-0003-3216-5902
A DebnathDepartment of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.
Y M ChangResearch Support Office, Royal Veterinary College, University of London, London, UK.
R C FowkesDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.
J ElliottDepartment of Comparative Biomedical Sciences, Royal Veterinary College, University of London, London, UK.
H M SymeDepartment of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.
University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperthyroidism is very common in older cats, but the etiopathogenesis is poorly understood. Decreased risk of hyperthyroidism has been reported in certain colorpoint breeds, and this observation previously has been hypothesized to result from relatively greater tyrosine availability for thyroid hormone production because of limited ability to convert tyrosine to melanin pigment. However, studies investigating a potential link between coat pigmentation and risk of hyperthyroidism are limited.

objectiveTo identify associations between coat phenotype and hyperthyroidism by investigation of breed, coat color, and hair length as risk factors for the disease. ANIMALS: Data were used from 4,705 cats aged ≥10 years, referred to a single veterinary teaching hospital (2006-2014) in the United Kingdom.

methodsRetrospective, epidemiological, cross-sectional study using Bayesian multivariable logistic regression to assess risk factors for hyperthyroidism.

resultsBurmese (odds ratio [OR], 0.01; 0.00-0.23; P = .004), Tonkinese (OR, 0.05; 0.00-0.95; P = .046), Persian (OR, 0.21; 0.10-0.44; P < .001), Siamese (OR, 0.27; 0.12-0.61; P = .002), Abyssinian (OR, 0.04; 0.00-0.74; P = .031), and British shorthair (OR, 0.47; 0.28-0.79; P = .004) breeds had decreased risk of hyperthyroidism compared to domestic shorthairs. Longhaired, nonpurebred cats (OR, 1.30; 1.03-1.64; P = .028) were at increased risk of hyperthyroidism. Coat color/pattern was not associated with hyperthyroidism in nonpurebred cats. CONCLUSIONS AND CLINICAL IMPORTANCE: We identified decreased risk of hyperthyroidism in the Tonkinese, Abyssinian, and British shorthair breeds, identified an association between risk of hyperthyroidism and hair length, and confirmed decreased risk in Burmese, Siamese, and Persian breeds. Additional studies are warranted to further investigate these findings.

Indexed as

Hair ColorAnimal FurAnimalsBayes TheoremCat DiseasesCatsCross-Sectional StudiesFemaleHyperthyroidismMalePhenotypeRetrospective StudiesRisk FactorsSpecies SpecificityCatPigmentTyrosinaseTyrosine

Identifiers

PMID28612380
PMCPMC5508346
OpenAlexW2625843134

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.