ArticleMicrobial biotechnology2017
First report on a novel Nigrospora sphaerica isolated from Catharanthus roseus plant with anticarcinogenic properties.
Article in Microbial biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- Untapped Mycobiota: A Scoping Review of Endophytic Fungi in Medicinal Plants from Malaysia.Journal of fungi (Basel, Switzerland) · 2026Review
- Sustainable vinblastine production by3 Biotech · 2025Article
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- Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges.3 Biotech · 2023Review
- Report on Vincristine-Producing Endophytic FungusMetabolites · 2022Article
- Portable solid-state sensor for therapeutic monitoring of an antineoplastic drug; vinblastine in human plasma.RSC advances · 2020Article
- Antifungal Activities of Volatile Secondary Metabolites of FourJournal of fungi (Basel, Switzerland) · 2018Article
- Importance of producing economic compounds to combat cancer.Microbial biotechnology · 2017Article
- First report on a novel Nigrospora sphaerica isolated from Catharanthus roseus plant with anticarcinogenic properties.Microbial biotechnology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reports on the vinca alkaloid produced by a novel Nigrospora sphaerica isolated from Catharanthus roseus. Through liquid chromatography-mass spectrometry (LCMS), only the crude mycelia extract of this fungus was positive for determination of vinblastine. This vinca alkaloid was then purified by using high-performance liquid chromatography (HPLC) and tested for cytotoxicity activity using MTT assays. The breast cell line cancer (MDA-MB 231) was treated with a purified vinblastine which was intracellulary produced by N. sphaerica. The purified vinblastine from extracted leaf of C. roseus was used as a standard comparison. A positive result with a value of half maximal inhibitory concentration (IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.