Evidence map›Paper›PMID 28612286›Full record

ArticleJournal of endocrinological investigation2018

Placental and maternal serum activin A in spontaneous and induced labor in late-term pregnancy.

L Funghi, M Torricelli, R Novembri, S Vannuccini, G Cevenini, M Di Tommaso, F M Severi, F Petraglia

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07637318 (Evaluation of Biomarkers in Term Labor Induction in Low-Risk Nulliparous Patients), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07637318 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of Biomarkers in Term Labor Induction in Low-Risk Nulliparous Patients: Toward Better Prediction of Induction Outcomes

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2026 to 2028Enrolled190ConditionsNulliparous Patient With Unfavourable Cervix, Undergoing Labor Induction at Term ≥ 39SAArmsVaginal sample
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

L FunghiObstetrics and Gynecology, Department of Molecular and Developmental Medicine, University of Siena, Policlinico "Santa Maria alle Scotte" Viale Bracci, 53100, Siena, Italy.
M TorricelliObstetrics and Gynecology, Department of Molecular and Developmental Medicine, University of Siena, Policlinico "Santa Maria alle Scotte" Viale Bracci, 53100, Siena, Italy.
R NovembriObstetrics and Gynecology, Department of Molecular and Developmental Medicine, University of Siena, Policlinico "Santa Maria alle Scotte" Viale Bracci, 53100, Siena, Italy.
S VannucciniObstetrics and Gynecology, Department of Molecular and Developmental Medicine, University of Siena, Policlinico "Santa Maria alle Scotte" Viale Bracci, 53100, Siena, Italy.
G CeveniniDepartment of Medical Biotechnology, University of Siena, Siena, Italy.
M Di TommasoDepartment of Health Sciences, University of Florence, Florence, Italy.
F M SeveriObstetrics and Gynecology, Department of Molecular and Developmental Medicine, University of Siena, Policlinico "Santa Maria alle Scotte" Viale Bracci, 53100, Siena, Italy.
F PetragliaObstetrics and Gynecology, Department of Molecular and Developmental Medicine, University of Siena, Policlinico "Santa Maria alle Scotte" Viale Bracci, 53100, Siena, Italy. felice.petraglia@unisi.it.
University of Siena · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFeto-placental unit represents an important source of activin A, a member of transforming growth factors-β involved in the mechanisms of labor. No evidences are available on activin A in pregnancies beyond 41 weeks of gestation, where induction of labor is often required. The present study aimed to evaluate activin A maternal serum levels and placental mRNA expression in term and late-term pregnancy, with spontaneous or induced labor, and its possible role to predict the response to labor induction.

methodsMaternal serum samples and placental specimens were collected from women with singleton pregnancy admitted for either term spontaneous labor (n = 23) or induction of labor for late-term pregnancy (n = 41), to evaluate activin A serum levels and placental mRNA expression. Univariate and multivariate analyses on activin A serum levels, maternal clinical parameters, and cervical length were conducted in women undergoing induction of labor.

resultsMaternal serum activin A levels and placental activin A mRNA expression in late-term pregnancies were significantly higher than at term. Late-term pregnancies who did not respond to induction of labor showed significantly lower levels of activin A compared to responders. The combination of serum activin A and cervical length achieved a sensitivity of 100% and a specificity of 93.55% for the prediction of successful induction.

conclusionLate-term pregnancy is characterized by hyperexpression of placental activin A and increased maternal activin A secretion. By combining maternal serum activin A levels with cervical length, a good predictive model for the response to induction of labor was elaborated.

Indexed as

Labor, InducedActivinsAdultBiomarkersFemaleHumansLabor OnsetLabor Stage, FirstPlacentaPregnancyProspective Studiesactivin AActivinsBiomarkersActivin ACervical lengthInduction of laborLate-term pregnancy

Identifiers

PMID28612286
OpenAlexW2626844018

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.