Evidence map›Paper›PMID 28612258›Full record

ArticleMolecular neurobiology2018

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.

Carolina Cunha, Catarina Santos, Cátia Gomes, Adelaide Fernandes, Alexandra Marçal Correia, Ana Maria Sebastião, Ana Rita Vaz, Dora Brites

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
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  12. Inflammasomes in neurodegenerative diseases.Translational neurodegeneration · 2024
    Review
  13. Article
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  15. Anti-Inflammatory Effects of MiyakoInternational journal of molecular sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Carolina CunhaNeuron Glia Biology in Health and Disease Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003, Lisbon, Portugal.
Catarina SantosNeuron Glia Biology in Health and Disease Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003, Lisbon, Portugal.
Cátia GomesNeuron Glia Biology in Health and Disease Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003, Lisbon, Portugal.
Adelaide FernandesNeuron Glia Biology in Health and Disease Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003, Lisbon, Portugal.
Alexandra Marçal CorreiaMuseu Nacional de História Natural e da Ciência, Universidade de Lisboa, Lisbon, Portugal.
Ana Maria SebastiãoInstituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Ana Rita VazNeuron Glia Biology in Health and Disease Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003, Lisbon, Portugal.
Dora BritesNeuron Glia Biology in Health and Disease Group, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003, Lisbon, Portugal. dbrites@ff.ulisboa.pt.ORCID http://orcid.org/0000-0002-3024-9777
University of Lisbon · PT

Funding

Relation of diet quality with mortalityR03CA091316 · NCI · QUEENS COLLEGE · PI KANT, ASHIMA K · 2001 to 2002
$154k
Fundação para a Ciência e a Tecnologia PTDC/SAU-FAR/118787/2010Fundação para a Ciência e a Tecnologia SFRH/BD/102718/2014Fundação para a Ciência e a Tecnologia SFRH/BD/91316/2012Fundação para a Ciência e a Tecnologia SFRH/BPD/76590/2011Fundação para a Ciência e a Tecnologia UID/DTP/04138/2013Research Grant of the Santa Casa Scientific Research Program on ALS ELA-2015-002
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of unknown cause. Absence of specific targets and biomarkers compromise the development of new therapeutic strategies and of innovative tools to stratify patients and assess their responses to treatment. Here, we investigate changes in neuroprotective-neuroinflammatory actions in the spinal cord of SOD1

Indexed as

Down-RegulationAmyotrophic Lateral SclerosisAnimalsAstrocytesBiomarkersCell CommunicationCell CountDisease Models, AnimalGene Expression ProfilingHMGB1 ProteinHomeostasisHumansInflammasomesInflammationInterleukin-6Mice, TransgenicBiomarkersHMGB1 ProteinInflammasomesInterleukin-6MicroRNAsMirn155 microRNA, mouseNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseSuperoxide Dismutase-1Tumor Necrosis Factor-alphaALS biomarkersAstrocytes and microglia functionInflamma-miRNAsMotor neuron-glia communicationPresymptomatic and symptomatic stagesTransgenic SOD1G93A mice

Identifiers

PMID28612258
OpenAlexW2625308621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.