Evidence map›Paper›PMID 28612257›Full record

SynthesisMolecular neurobiology2018

Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis.

Cristiano A Köhler, Thiago H Freitas, Brendon Stubbs, Michael Maes, Marco Solmi, Nicola Veronese, Nayanna Q de Andrade, Gerwyn Morris, Brisa S Fernandes, André R Brunoni and 5 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 242 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
242citing papers in PubMed, 14 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

242 citing papers in PubMed, 14 syntheses or guidelines pooled it, 446 citations in OpenAlex.

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  5. Antidepressants for COVID-19: A systematic review.Journal of affective disorders · 2022
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182 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 12 institutions in 8 countries.

Cristiano A KöhlerTranslational Psychiatry Research Group and Department of Clinical Medicine, Faculty of Medicine, Fortaleza, CE, Brazil.
Thiago H FreitasTranslational Psychiatry Research Group and Department of Clinical Medicine, Faculty of Medicine, Fortaleza, CE, Brazil.
Brendon StubbsPhysiotherapy Department, South London and Maudsley, NHS Foundation Trust, London, UK.
Michael MaesIMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.
Marco SolmiDepartment of Neurosciences, University of Padova, Padova, Italy.
Nicola VeroneseInstitute of Clinical Research and Education in Medicine (IREM), Padua, Italy.
Nayanna Q de AndradeTranslational Psychiatry Research Group and Department of Clinical Medicine, Faculty of Medicine, Fortaleza, CE, Brazil.
Gerwyn MorrisIMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.
Brisa S FernandesIMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Australia.
André R BrunoniCenter for Clinical and Epidemiological Research & Interdisciplinary Center for Applied Neuromodulation (CINA), University Hospital, University of São Paulo, São Paulo, Brazil.
Nathan HerrmannNeuropsychopharmacology Research Group, Hurvitz Brain Sciences Program Sunnybrook Research Institute, Toronto, ON, Canada.
Charles L RaisonDepartment of Human Development and Family Studies, School of Human Ecology, University of Wisconsin-Madison, 1300 Linden Drive, Room 4174, Madison, WI, 53705, USA.
Brian J MillerDepartment of Psychiatry & Health Behavior, Georgia Regents University, Augusta, GA, USA.
Krista L LanctôtNeuropsychopharmacology Research Group, Hurvitz Brain Sciences Program Sunnybrook Research Institute, Toronto, ON, Canada.
André F CarvalhoTranslational Psychiatry Research Group and Department of Clinical Medicine, Faculty of Medicine, Fortaleza, CE, Brazil. andrefc7@terra.com.br.ORCID http://orcid.org/0000-0001-5593-2778
Universidade de Fortaleza · BRSunnybrook Health Science Centre · CAAugusta University · USDeakin University · AUKing's College London · GBNeuroscience Institute · ITUniversidade de São Paulo · BRUniversidade Estadual de Londrina · BRUniversidade Federal do Ceará · BRUniversidade Federal do Rio Grande do Sul · BRUniversity of Padua · ITUniversity of Wisconsin–Madison · US

Funding

Department of Health ICA-CL-2017-03-001
6 · The paper itself

Abstract

Mounting evidence suggests that aberrations in immune-inflammatory pathways contribute to the pathophysiology of major depressive disorder (MDD), and individuals with MDD may have elevated levels of predominantly pro-inflammatory cytokines and C-reactive protein. In addition, previous meta-analyses suggest that antidepressant drug treatment may decrease peripheral levels of interleukin-1 beta (IL-1β) and IL-6. Recently, several new studies examining the effect of antidepressants on these cytokines have been published, and so we performed an updated meta-analysis of studies that measured peripheral levels of cytokines and chemokines during antidepressant treatment in patients with MDD. The PubMed/MEDLINE, EMBASE, and PsycInfo databases were searched from inception through March 9, 2017. Forty-five studies met inclusion criteria (N = 1517). Peripheral levels of IL-6, tumor necrosis factor-alpha (TNF-α), IL-1β, IL-10, IL-2, IL-4, interferon-γ, IL-8, the C-C motif ligand 2 chemokine (CCL-2), CCL-3, IL-1 receptor antagonist, IL-13, IL-17, IL-5, IL-7, and the soluble IL-2 receptor were measured in at least three datasets and thus were meta-analyzed. Antidepressant treatment significantly decreased peripheral levels of IL-6 (Hedges g = -0.454, P <0.001), TNF-α (g = -0.202, P = 0.015), IL-10 (g = -0.566, P = 0.012), and CCL-2 (g = -1.502, P = 0.006). These findings indicate that antidepressants decrease several markers of peripheral inflammation. However, this meta-analysis did not provide evidence that reductions in peripheral inflammation are associated with antidepressant treatment response although few studies provided separate data for treatment responders and non-responders.

Indexed as

Antidepressive AgentsChemokinesHumansMajor Depressive DisorderTreatment OutcomeAntidepressive AgentsChemokinesAntidepressantChemokinesCytokinesDepressionInflammationMeta-analysis

Identifiers

PMID28612257
OpenAlexW2624751168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.