ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2017
Using optogenetics to assess neuroendocrine modulation of heart rate in Drosophila melanogaster larvae.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The Effect of Magnesium Concentration on Myogenic Cardiac Function: LarvalmicroPublication biology · 2024Article
- Article
- Developing Drosophila melanogaster Models for Imaging and Optogenetic Control of Cardiac Function.Journal of visualized experiments : JoVE · 2022Article
- Examining the effect of manganese on physiological processes: Invertebrate models.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2022Article
- Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila.Cellular and molecular life sciences : CMLS · 2021Review
- Cardiac optogenetics: a decade of enlightenment.Nature reviews. Cardiology · 2021Review
- Smoking flies: testing the effect of tobacco cigarettes on heart function ofBiology open · 2021Article
- Effect of Temperature on Heart Rate forInsects · 2021Article
- Neurohumoral Cardiac Regulation: Optogenetics Gets Into the Groove.Frontiers in physiology · 2021Review
- Feasibility of Using Adjunctive Optogenetic Technologies in Cardiomyocyte Phenotyping - from the Single Cell to the Whole Heart.Current pharmaceutical biotechnology · 2020Review
- The Effects of Chloride Flux onMethods and protocols · 2019Article
- A Light Wand to Untangle the Myocardial Cell Network.Methods and protocols · 2019Review
- Hyperpolarization by activation of halorhodopsin results in enhanced synaptic transmission: Neuromuscular junction and CNS circuit.PloS one · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The Drosophila melanogaster heart has become a principal model in which to study cardiac physiology and development. While the morphology of the heart in Drosophila and mammals is different, many of the molecular mechanisms that underlie heart development and function are similar and function can be assessed by similar physiological measurements, such as cardiac output, rate, and time in systole or diastole. Here, we have utilized an intact, optogenetic approach to assess the neural influence on heart rate in the third instar larvae. To simulate the release of modulators from the nervous system in response to environmental influences, we have directed expression of channel-rhodopsin variants to targeted neuronal populations to assess the role of these neural ensembles in directing release of modulators that may affect heart rate in vivo. Our observations show that the activation of targeted neurons, including cholinergic, dopaminergic, and serotonergic neurons, stimulate the release of cardioactive substances that increase heart rate after the initial activation at both room temperature and in a cold environment. This parallels previous studies suggesting these modulators play a crucial role in altering heart rate when applied to exposed hearts and adds to our understanding of chemical modulation of heart rate in intact Drosophila larvae.
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