Evidence map›Paper›PMID 28612194›Full record

ArticleDigestive diseases and sciences2017

Clinical and Pathological Risk Factors Associated with Liver Fibrosis and Steatosis in African-Americans with Chronic Hepatitis C.

Ali Afsari, Edward Lee, Babak Shokrani, Tina Boortalary, Zaki A Sherif, Mehdi Nouraie, Adeyinka O Laiyemo, Kawtar Alkhalloufi, Hassan Brim, Hassan Ashktorab

Open access · greenAbstract read
In one paragraph

Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Steatotic liver disease and chronic viral hepatitis.Clinical and experimental hepatology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ali AfsariDepartment of Medicine and Cancer Research Center, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, DC, 20060, USA.
Edward LeeDepartment of Pathology, Howard University College of Medicine, Washington, DC, USA.
Babak ShokraniDepartment of Pathology, Howard University College of Medicine, Washington, DC, USA.
Tina BoortalaryDepartment of Medicine and Cancer Research Center, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, DC, 20060, USA.
Zaki A SherifDepartment of Medicine and Cancer Research Center, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, DC, 20060, USA.
Mehdi NouraieDepartment of Medicine and Vascular Institute Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Adeyinka O LaiyemoDepartment of Medicine and Cancer Research Center, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, DC, 20060, USA.
Kawtar AlkhalloufiDepartment of Medicine and Cancer Research Center, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, DC, 20060, USA.
Hassan BrimDepartment of Medicine and Cancer Research Center, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, DC, 20060, USA.
Hassan AshktorabDepartment of Medicine and Cancer Research Center, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, DC, 20060, USA. hashktorab@howard.edu.ORCID 0000-0002-4048-4666
Howard University · USUniversity of Pittsburgh · US

Funding

PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
Analysis of Racial Disparities in HCC by Systems MetabolomicsU01CA185188 · NCI · GEORGETOWN UNIVERSITY · PI RESSOM, HABTOM W · 2015 to 2019
$1.7M
NCI NIH HHS U01 CA185188NIMHD NIH HHS G12 MD007597
6 · The paper itself

Abstract

BACKGROUND AND

aimSeveral factors involved in the development of liver fibrosis in African-American patients with chronic hepatitis C have not been well studied. We aimed to evaluate some of these risk factors.

methodsWe reviewed pathology and medical records of 603 African-Americans with chronic hepatitis C virus (HCV) infection at Howard University Hospital from January 2004 to December 2013. Among the clinical and pathological data collected were HIV (human immunodeficiency virus), HCV genotype, hepatitis B virus (HBV), diabetes mellitus (DM), hypertension (HTN), body mass index (BMI), and hepatic steatosis.

resultsThe frequency of DM, HTN, HIV, and HBV was 22, 16, 11, and 4%, respectively. Median BMI was 27.3 kg/m

conclusionThis study shows that steatosis is independently associated with fibrosis in African-American patients with HCV infection. Female patients were at higher risk of steatosis.

Indexed as

HepacivirusAdultAgedAged, 80 and overAge FactorsBlack or African AmericanBody WeightFatty LiverFemaleHepatitis C, ChronicHIV InfectionsHumansLiver CirrhosisLogistic ModelsMaleMiddle AgedAfrican-AmericansFibrosisHCVHepatitis

Identifiers

PMID28612194
PMCPMC5706543
OpenAlexW2624759913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.