Evidence map›Paper›PMID 28612123›Full record

Trial reportEuropean journal of applied physiology2017

The influence of vitamin C on the interaction between acute mental stress and endothelial function.

Meghan D Plotnick, Katrina A D'Urzo, Brendon J Gurd, Kyra E Pyke

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Mental stress induces endothelial dysfunction by AT1R-mediated redox imbalance in overweight/obese men.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Vitamin C and Cardiovascular Disease: An Update.Antioxidants (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Meghan D PlotnickSchool of Kinesiology and Health Studies, Queen's University, 28 Division St., Kingston, ON, K7L 3N6, Canada.
Katrina A D'UrzoSchool of Kinesiology and Health Studies, Queen's University, 28 Division St., Kingston, ON, K7L 3N6, Canada.
Brendon J GurdSchool of Kinesiology and Health Studies, Queen's University, 28 Division St., Kingston, ON, K7L 3N6, Canada.
Kyra E PykeSchool of Kinesiology and Health Studies, Queen's University, 28 Division St., Kingston, ON, K7L 3N6, Canada. pykek@queensu.ca.
Queen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine whether orally administered vitamin C attenuates expected mental stress-induced reductions in brachial artery endothelial function as measured by flow-mediated dilation (FMD).

methodsFifteen men (21 ± 2 years) were given 1000 mg of vitamin C or placebo over two visits in a randomized, double-blinded, within-subject design. Acute mental stress was induced using the Trier Social Stress Test (TSST). Saliva samples for cortisol determination and FMD measures were obtained at baseline, pre-TSST, and 30 and 90-min post-TSST. An additional saliva sample was obtained immediately post-TSST. Cardiovascular stress reactivity was characterized by changes in heart rate (HR) and mean arterial pressure (MAP).

resultsA significant stress response was elicited by the TSST in both conditions [MAP, HR, and salivary cortisol increased (p < 0.001)]. Overall FMD did not differ pre- vs. post-stress (time: p = 0.631) and there was no effect of vitamin C (condition: p = 0.792) (interaction between time and condition, p = 0.573). However, there was a correlation between cortisol reactivity and changes in FMD from pre- to post-stress in the placebo condition (r

conclusionAcute mental stress did not impair endothelial function, and vitamin C disrupted the relationship between cortisol reactivity and changes in FMD post-stress. This suggests that acute mental stress does not universally impair endothelial function and that reactive oxygen species signaling may influence the interaction between FMD and stress responses.

Indexed as

Ascorbic AcidBlood Flow VelocityBlood PressureBrachial ArteryDouble-Blind MethodEndothelium, VascularHeart RateHumansHydrocortisoneMaleOxidative StressRegional Blood FlowSalivaStress, PsychologicalYoung AdultAscorbic AcidHydrocortisoneAntioxidantCortisolFlow-mediated dilationFMDHPA axisReactive oxygen speciesROSStress reactivityTrier Social Stress Test

Identifiers

PMID28612123
OpenAlexW2624849022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.