Evidence map›Paper›PMID 28612089›Full record

ReviewIntensive care medicine2017

The intensive care delirium research agenda: a multinational, interprofessional perspective.

Pratik P Pandharipande, E Wesley Ely, Rakesh C Arora, Michele C Balas, Malaz A Boustani, Gabriel Heras La Calle, Colm Cunningham, John W Devlin, Julius Elefante, Jin H Han and 12 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 7 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 7 syntheses or guidelines pooled it, 213 citations in OpenAlex.

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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 20 institutions in 10 countries.

Pratik P PandharipandeDivision of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA. Pratik.pandharipande@vanderbilt.edu.ORCID http://orcid.org/0000-0002-1389-8580
E Wesley ElyDivision of Pulmonary and Critical Care and Health Services Research, Vanderbilt University and VA-GRECC, Nashville, TN, USA.
Rakesh C AroraDepartment of Surgery, St. Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada.
Michele C BalasCenter of Excellence in Critical and Complex Care, College of Nursing, The Ohio State University, Columbus, OH, USA.
Malaz A BoustaniIndiana University Center for Health Innovation and Implementation Science, Indianapolis, IN, USA.
Gabriel Heras La CalleInternational Research Project Humanizing Intensive Care (Proyecto HU-CI), Intensive Care Unit, Hospital Universitario de Torrejón, Madrid, Spain.
Colm CunninghamSchool of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Lloyd Institute, Trinity College Dublin, Dublin, Ireland.
John W DevlinSchool of Pharmacy, Northeastern University, Boston, USA.
Julius ElefanteDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Jin H HanDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Alasdair M MacLullichEdinburgh Delirium Research Group, Geriatric Medicine Unit, University of Edinburgh, Edinburgh, Scotland, UK.
José R MaldonadoStanford University School of Medicine, Stanford, CA, USA.
Alessandro MorandiDepartment of Rehabilitation, Ancelle Hospital, Cremona, Italy.
Dale M NeedhamDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Valerie J PageWatford General Hospital, Watford, UK.
Louise RoseSunnybrook Health Sciences Centre, Toronto, Canada.
Jorge I F SalluhDepartment of Critical Care, rD' OR Institute for Research and Education and Post-Graduate Program Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Tarek SharsharDepartment of Intensive Care Medicine, Raymond Poincaré Hospital, Paris, France.
Yahya ShehabiSchool of Clinical Sciences, Faculty of Medicine, Monash University and Medical Center, Melbourne, Australia.
Yoanna SkrobikDepartment of Medicine, McGill University, Montreal, Canada.
Arjen J C SlooterDepartment of Intensive Care Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Heidi A B SmithDivision of Pediatric Cardiac Anesthesia, Department of Anesthesiology and Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
Vanderbilt University Medical Center · USCa' Foncello Hospital · ITHospital Universitario de Torrejón · ESIndiana University Health · USInstitut Pasteur · FRJohns Hopkins University · USMcGill University · CAMonroe Carell Jr. Children's Hospital · USStanford University · USSt. Boniface Hospital · CASunnybrook Health Science Centre · CAThe Ohio State University · USTrinity College Dublin · IETufts Medical Center · USUniversidade Federal do Rio de Janeiro · BRUniversity of British Columbia · CAUniversity of Edinburgh · GBUNSW Sydney · AUUtrecht University · NLVanderbilt University · US

Funding

The MIND USA StudyR01AG035117 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ELY, E WESLEY · 2011 to 2016
$7.3M
Improving Long-Term Outcomes Clinical Research for Acute Respiratory FailureR24HL111895 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NEEDHAM, DALE MURRAY · 2013 to 2017
$5.4M
Supplement to Network for Investigation of Delirium across the U.S (NIDUS)R24AG054259 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2016 to 2020
$4.3M
Altering Sedation Paradigms to Improve Brain Injury and Survival in Severe SepsisR01HL111111 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PANDHARIPANDE, PRATIK · 2012 to 2017
$3.7M
European Union H2020-PHC-12-2014-672974NHLBI NIH HHS R01 HL111111NHLBI NIH HHS R24 HL111895NIA NIH HHS R01 AG035117NIA NIH HHS R24 AG054259NIH HHS 1R21G04567212NIH HHS R01AG035117NIH HHS R01HL111111NIH HHS R24AG054259NIH HHS R24HL111895Technology Foundation STW 14066
6 · The paper itself

Abstract

Delirium, a prevalent organ dysfunction in critically ill patients, is independently associated with increased morbidity. This last decade has witnessed an exponential growth in delirium research in hospitalized patients, including those critically ill, and this research has highlighted that delirium needs to be better understood mechanistically to help foster research that will ultimately lead to its prevention and treatment. In this invited, evidence-based paper, a multinational and interprofessional group of clinicians and researchers from within the fields of critical care medicine, psychiatry, pediatrics, anesthesiology, geriatrics, surgery, neurology, nursing, pharmacy, and the neurosciences sought to address five questions: (1) What is the current standard of care in managing ICU delirium? (2) What have been the major recent advances in delirium research and care? (3) What are the common delirium beliefs that have been challenged by recent trials? (4) What are the remaining areas of uncertainty in delirium research? (5) What are some of the top study areas/trials to be done in the next 10 years? Herein, we briefly review the epidemiology of delirium, the current best practices for management of critically ill patients at risk for delirium or experiencing delirium, identify recent advances in our understanding of delirium as well as gaps in knowledge, and discuss research opportunities and barriers to implementation, with the goal of promoting an integrated research agenda.

Indexed as

Outcome Assessment, Health CareAge FactorsAntipsychotic AgentsBiomedical ResearchCognitive DysfunctionCritical IllnessDeep SedationDeliriumEvidence-Based MedicineHumansIntensive Care UnitsRandomized Controlled Trials as TopicRespiration, ArtificialRisk FactorsAntipsychotic AgentsCognitive impairmentDeliriumResearch agenda

Identifiers

PMID28612089
PMCPMC5709210
OpenAlexW2625447343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.