ReviewFrontiers in immunology2017
Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis.
Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Identification of Soluble Mediators in IgG-Mediated Anaphylaxis via Fcγ Receptor: A Meta-Analysis.Frontiers in immunology · 2019Pooled it
- Drug-induced anaphylaxis: Molecular pathophysiology, diagnosis, and management.Asia Pacific allergy · 2026Article
- Hereditary Alpha-Tryptasemia (HαT) as a Risk Modifier for Severe Anaphylaxis.Immunology and allergy clinics of North America · 2026Review
- Comprehensive Study of Drug-Associated Severe Allergic Reactions: An Analysis of High-Risk Medications and Epidemiological Trends Based on the FAERS Database.Allergy, asthma & immunology research · 2026Article
- Genetic variations associated with immediate hypersensitivity reactions to iodinated contrast media: A whole exome sequencing study.PloS one · 2026Article
- Descriptive analysis of anaphylactic events reported in the FDA Adverse Event Reporting System (FAERS).Journal of public health research · 2026Article
- Acute Allergic Reactions and Severe Anaphylaxis: Underlying Causes, Management Strategies, and Future Directions.Archives of internal medicine research · 2026Article
- Characteristics of Allergy-related Emergency Medical Calls: A Retrospective Dispatch-based Study.Zdravstveno varstvo · 2025Article
- Severe anaphylactic reaction to contrast agent: teams are well prepared but should simulate the situations regularly.The British journal of radiology · 2025Article
- Pediatric Anaphylaxis in the Emergency Department: From Mechanisms to Personalized Care.Cureus · 2025Review
- Severe drug-associated anaphylaxis: a complementary descriptive analyses of registry cases and spontaneous reports.European journal of clinical pharmacology · 2025Article
- Hypofibrinogenemia Following an Anaphylactic Shock Caused by a Neuromuscular Blocking Agent-Case Report.Case reports in critical care · 2025Article
- 10 practical priorities to prevent and manage serious allergic reactions: GAClinical and translational allergy · 2024Review
- Trust but Verify: Lessons Learned for the Application of AI to Case-Based Clinical Decision-Making From Postmarketing Drug Safety Assessment at the US Food and Drug Administration.Journal of medical Internet research · 2024Article
- Anaphylaxis and Severe Disseminated Intravascular Coagulation Due to Remdesivir.Internal medicine (Tokyo, Japan) · 2024Article
- The Application of Knowledge-Based Clinical Decision Support Systems to Detect Antibiotic Allergy.Antibiotics (Basel, Switzerland) · 2024Article
- Evaluation of the Regulatory Required Post-Authorization Safety Study for Propacetamol: Nested Case-Control and Case-Time-Control Studies.Yonsei medical journal · 2024Article
- Immunological Mechanisms in Cutaneous Adverse Drug Reactions.Biomolecules & therapeutics · 2024Review
- Trends in Anaphylaxis Hospitalizations among Adults in Spain and Their Relationship with Asthma-Analysis of Hospital Discharge data from 2016 to 2021.Healthcare (Basel, Switzerland) · 2023Article
- Tools for Etiologic Diagnosis of Drug-Induced Allergic Conditions.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators by mast cells and basophils. Although anaphylaxis is often under-communicated and thus underestimated, its incidence appears to have risen over recent decades. Drugs are among the most common triggers in adults, being analgesics and antibiotics the most common causal agents. Anaphylaxis can be caused by immunologic or non-immunologic mechanisms. Immunologic anaphylaxis can be mediated by IgE-dependent or -independent pathways. The former involves activation of Th2 cells and the cross-linking of two or more specific IgE (sIgE) antibodies on the surface of mast cells or basophils. The IgE-independent mechanism can be mediated by IgG, involving the release of platelet-activating factor, and/or complement activation. Non-immunological anaphylaxis can occur through the direct stimulation of mast cell degranulation by some drugs, inducing histamine release and leading to anaphylactic symptoms. Work-up of a suspected drug-induced anaphylaxis should include clinical history; however, this can be unreliable, and skin tests should also be used if available and validated. Drug provocation testing is not recommended due to the risk of inducing a harmful reaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.