ArticleFrontiers in physiology2017
Monitoring Notch Signaling-Associated Activation of Stem Cell Niches within Injured Dental Pulp.
Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Neural biomarkers in pulpitis and their associations with inflammation and pain perception: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Identification of GLDNInternational journal of oral science · 2026Article
- Notch2 is involved in regulating apical tissue repair following severe intrusive luxation.Journal of applied oral science : revista FOB · 2026Article
- An Innovative "Tooth-On-Chip" Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue.Advanced healthcare materials · 2026Article
- Long-Term Biobanked Dental Pulp Stem Cells Retain Angiogenic Potential for Vascularised Tissue Engineering-Laboratory Investigation.International endodontic journal · 2026Article
- Mutanobactin-D, aInternational journal of molecular sciences · 2025Article
- The Migration and the Fate of Dental Pulp Stem Cells.Biology · 2023Review
- The Genes Involved in Dentinogenesis.Organogenesis · 2022Article
- Parallels in signaling between development and regeneration in ectodermal organs.Current topics in developmental biology · 2022Article
- Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease.International journal of molecular sciences · 2021Review
- Notch signaling in the dynamics of perivascular stem cells and their niches.Stem cells translational medicine · 2021Article
- Histology-based profile of inflammatory mediators in experimentally induced pulpitis in a rat model: screening for possible biomarkers.International endodontic journal · 2021Article
- A single-cell atlas of human teeth.iScience · 2021Article
- Distinct Expression Patterns of Cxcl12 in Mesenchymal Stem Cell Niches of Intact and Injured Rodent Teeth.International journal of molecular sciences · 2021Article
- Article
- Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation.Nature communications · 2019Article
- Indirect immobilized Jagged1 suppresses cell cycle progression and induces odonto/osteogenic differentiation in human dental pulp cells.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental pulp stem/progenitor cells guarantee tooth homeostasis, repair and regeneration throughout life. The decision between renewal and differentiation of these cells is influenced by physical and molecular interactions with stromal cells and extracellular matrix molecules forming the specialized microenvironment of dental pulp stem cell niches. Here we study the activation of putative pulp niches after tooth injury through the upregulation of Notch signaling pathway. Notch1, Notch2, and Notch3 molecules were used as markers of dental pulp stem/progenitor cells. Upon dental injury, Notch1 and Notch3 are detected in cells related to vascular structures suggesting a role of these proteins in the activation of specific pulpal perivascular niches. In contrast, a population of Notch2-positive cells that are actively proliferative is observed in the apical part of the pulp. Kinetics of these cells is followed up with a lipophilic DiI labeling, showing that apical pulp cells migrate toward the injury site where dynamic regenerative/repair events occur. The knowledge of the activation and regulation of dental pulp stem/progenitor cells within their niches in pathologic conditions may be helpful for the realization of innovative dental treatments in the near future.
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Registered trials
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