ReviewFrontiers in physiology2017
Pathways that Regulate ROS Scavenging Enzymes, and Their Role in Defense Against Tissue Destruction in Periodontitis.
Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06261723 (Effect of Non-chirurgical Periodontal Treatment on the Innate and Adaptive Immunity From a Gender Perspective), which is not on this map. Cited by 99 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Non-chirurgical Periodontal Treatment on the Innate and Adaptive Immunity From a Gender Perspective: Potential Therapeutic Implications of microRNAs
Who cites it
99 citing papers in PubMed, 2 syntheses or guidelines pooled it, 181 citations in OpenAlex.
- Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis.Nutrients · 2026Pooled it
- Microplastics in the Pathogenesis of Periodontal Diseases: A Narrative Review.Annals of global health · 2025Pooled it
- Hydrogen peroxide-based products alter inflammatory and tissue damage-related proteins in the gingival crevicular fluid of healthy volunteers: a randomized trial.Scientific reports · 2019Trial
- Antioxidant, Antibacterial, and Antivirulence Activities of a Bioactive Fraction fromAntioxidants (Basel, Switzerland) · 2026Article
- Wireless flexible patch based on ultrasound-responsive SenA@ZIF-8 release for on-demand medication of periodontitis.Journal of nanobiotechnology · 2026Article
- Multifunctional injectable hydrogel with Zn-metformin coordination for synergistic anti-infection, antioxidant, and osteogenic therapy in periodontitis.Materials today. Bio · 2026Article
- Resveratrol supplementation as a non-surgical treatment in periodontitis and related systemic conditions.Journal of traditional and complementary medicine · 2026Review
- Cascade Therapy of Periodontitis via Sequential Release of Ribosome-Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF-Based System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An antioxidant and antibacterial octyl gallate sustained-release ointment for periodontitis treatment.iScience · 2026Article
- Relationship between oral microbiota and chronic kidney disease: facts and perspectives.Journal of oral microbiology · 2026Review
- Exosomes from LPS-pretreated BMSCs treated periodontitis via improving oxidative stress.Stem cell research & therapy · 2025Article
- Effect of resveratrol on the antioxidant enzyme pathway and alveolar bone loss in experimental periodontitis.Acta odontologica Scandinavica · 2025Article
- Low-intensity pulsed ultrasound alleviates periodontitis in mice with T2DM through Nrf2 pathway.APL bioengineering · 2025Article
- Neutrophils at the Crossroads of Oral Microbiome Dysbiosis and Periodontal Disease.Microorganisms · 2025Review
- The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target.Immunity, inflammation and disease · 2025Review
- Protective and therapeutic effects of hexagonal boron nitride against hydrogen peroxide-induced oxidative damage in human gingival fibroblasts.BMC oral health · 2025Article
- Curcumin-alendronate carbon dots: A dual-logic strategy for precision treatment of periodontitis.Materials today. Bio · 2025Article
- [Investigating the protective effect of naringenin on hydrogen peroxide induced oxidative damage of human periodontal ligament stem cells by regulating the forkhead box protein O-1/β-catenin pathway].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Article
- Superhydrophobic ROS biocatalytic metal coatings for the rapid healing of diabetic wounds.Materials today. Bio · 2025Article
- Association between composite dietary antioxidant index and the prevalence of periodontitis: results from NHANES 2009-2014.BMC oral health · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis, an inflammatory disease that affects the tissues surrounding the teeth, is a common disease worldwide. It is caused by a dysregulation of the host inflammatory response to bacterial infection, which leads to soft and hard tissue destruction. In particular, it is the excessive inflammation in response to bacterial plaque that leads to the release of reactive oxygen species (ROS) from neutrophils, which, then play a critical role in the destruction of periodontal tissue. Generally, ROS produced from immune cells exhibit an anti-bacterial effect and play a role in host defense and immune regulation. Excessive ROS, however, can exert cytotoxic effects, cause oxidative damage to proteins, and DNA, can interfere with cell growth and cell cycle progression, and induce apoptosis of gingival fibroblasts. Collectively, these effects enable ROS to directly induce periodontal tissue damage. Some ROS also act as intracellular signaling molecules during osteoclastogenesis, and can thus also play an indirect role in bone destruction. Cells have several protective mechanisms to manage such oxidative stress, most of which involve production of cytoprotective enzymes that scavenge ROS. These enzymes are transcriptionally regulated via NRF2, Sirtuin, and FOXO. Some reports indicate an association between periodontitis and these cytoprotective enzymes' regulatory axes, with superoxide dismutase (SOD) the most extensively investigated. In this review article, we discuss the role of oxidative stress in the tissue destruction manifest in periodontitis, and the mechanisms that protect against this oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.