Evidence map›Paper›PMID 28611663›Full record

ArticleFrontiers in pharmacology2017

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation.

Timothy D Hewitson, Stephen G Holt, Sven-Jean Tan, Belinda Wigg, Chrishan S Samuel, Edward R Smith

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Epigenetic memories induced by hypoxia in AKI-to-CKD transition.Clinical and experimental nephrology · 2025
    Review
  3. Review
  4. Review
  5. Epigenetic therapeutics attenuate kidney injury and fibrosis by restoring the expression of epigenetically reprogrammed fibrogenic genes and signaling pathways.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025
    Article
  6. New approaches to acute kidney injury.Clinical kidney journal · 2024
    Article
  7. Review
  8. Sex-specific modulation of renal epigenetic and injury markers in aging kidney.American journal of physiology. Renal physiology · 2024
    Article
  9. Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female Npr1 haplotype mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  10. Article
  11. Sex-specific epigenetic programming in renal fibrosis and inflammation.American journal of physiology. Renal physiology · 2023
    Review
  12. Article
  13. Kidney fibrosis: from mechanisms to therapeutic medicines.Signal transduction and targeted therapy · 2023
    Review
  14. Article
  15. Exploring the multifaceted role of TGF-β signaling in diabetic complications.Environmental science and pollution research international · 2022
    Review
  16. Review
  17. Review
  18. Epigenetics in kidney diseases.Advances in clinical chemistry · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Timothy D HewitsonDepartment of Nephrology, The Royal Melbourne Hospital, MelbourneVIC, Australia.
Stephen G HoltDepartment of Nephrology, The Royal Melbourne Hospital, MelbourneVIC, Australia.
Sven-Jean TanDepartment of Nephrology, The Royal Melbourne Hospital, MelbourneVIC, Australia.
Belinda WiggDepartment of Nephrology, The Royal Melbourne Hospital, MelbourneVIC, Australia.
Chrishan S SamuelCardiovascular Disease Program, Biomedicine Discovery Institute and Department of Pharmacology, Monash University, MelbourneVIC, Australia.
Edward R SmithDepartment of Nephrology, The Royal Melbourne Hospital, MelbourneVIC, Australia.
The Royal Melbourne Hospital · AUMonash University · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

epigeneticsfibroblastfibrosishistonekidneymyofibroblastproximal tubuleTGF-β1

Identifiers

PMID28611663
PMCPMC5447091
OpenAlexW2618947559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.