ArticleScientific reports2017
Evaluation of the immature platelet fraction contribute to the differential diagnosis of hereditary, immune and other acquired thrombocytopenias.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Applications of Extended Platelet Profiles in Clinical Practice.Diseases (Basel, Switzerland) · 2026Review
- Clinical Utility of an Increased Pretreatment Immature Platelet Fraction in the Early Diagnosis of TAFRO Syndrome, Especially in Patients with Late-onset Thrombocytopenia: A Case Series and Literature Review.Internal medicine (Tokyo, Japan) · 2025Review
- Diagnosis of Inherited Platelet Disorders: Clinical Evaluation and Functional and Molecular Assays.Biomolecules · 2025Review
- Early prediction of platelet recovery with immature platelet fraction in patients receiving hematopoietic stem cell transplantation.Annals of hematology · 2024Article
- Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition.International journal of hematology · 2024Article
- Open-label pilot study of romiplostim for thrombocytopenia after autologous hematopoietic cell transplantation.Blood advances · 2023Article
- Macrothrombocytopenia: Role of Automated Platelet Data in Diagnosis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023Article
- Novel Biomarkers for Diagnosis and Monitoring of Immune Thrombocytopenia.International journal of molecular sciences · 2023Review
- A familial case of MYH9 gene mutation associated with multiple functional and structural platelet abnormalities.Scientific reports · 2022Article
- Src-related thrombocytopenia: a fine line between a megakaryocyte dysfunction and an immune-mediated disease.Blood advances · 2022Article
- Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry.Blood advances · 2022Article
- Diagnostic workup of inherited platelet disorders.Blood research · 2022Review
- Routine and Advanced Laboratory Tests for Hemostasis Disorders in COVID-19 Patients: A Prospective Cohort Study.Journal of clinical medicine · 2022Article
- Consensus guidelines for the management of adult immune thrombocytopenia in Australia and New Zealand.The Medical journal of Australia · 2022Article
- Platelet features allow to differentiate immune thrombocytopenia from inherited thrombocytopenia.Annals of hematology · 2021Article
- Immature platelet fraction based diagnostic predictive scoring model for immune thrombocytopenia.The Korean journal of internal medicine · 2020Article
- Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC).Journal of clinical medicine · 2020Review
- Immature platelet fraction: A useful marker for identifying the cause of thrombocytopenia and predicting platelet recovery.Medicine · 2020Observational
- Immature Platelet Dynamics in Immune-Mediated Thrombocytopenic States.Frontiers in medicine · 2020Review
- Reference interval for immature platelet fraction on Sysmex XN haematology analyser in adult population.Biochemia medica · 2018Article
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Authors and funding
12 authors.
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Abstract
The differential diagnosis of immune (ITP) and hereditary macrothrombocytopenia (HM) is key to patient management. The immature platelet fraction (IPF) represents the subset of circulating platelets with higher RNA content, and has been shown to distinguish hypo- from hyperproliferative thrombocytopenias. Here we evaluated the diagnostic accuracy of IPF in the differential diagnosis between HM and other thrombocytopenias in a population of patients with post-chemotherapy thrombocytopenia (n = 56), bone marrow failure (n = 22), ITP (n = 105) and HM (n = 27). TPO levels were also measured in HM and ITP matched for platelet counts. Platelet counts were similar in all patient groups. Higher IPF values were observed in both ITP (12.3%; 2.4-65.6%) and HM (29.8%; 4.6-65.9%) compared to hypoproliferative thrombocytopenias. IPF values were also higher in HM compared to ITP, yielding a diagnostic accuracy of 0.80 (95%CI 0.70-0.90; P < 0.0001) to distinguish these two conditions. Intra- and inter-assays reproducibility of IPF in HM patients revealed that this is a stable parameter. In conclusion, IPF is increased in HM compared to both ITP and other thrombocytopenias and contributes to the differentiation between ITP and HM. Further studies are warranted to understand the biological rationale of these findings and to its incorporation in diagnostic algorithms of HM.
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