ArticleScientific reports2017
Canine Leishmaniasis Progression is Associated with Vitamin D Deficiency.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Trends and Gaps in the Scientific Literature about the Effects of Nutritional Supplements on Canine Leishmaniosis.Pathogens (Basel, Switzerland) · 2024Pooled it
- A Tailored Approach to Leishmaniases Vaccination: Comparative Evaluation of the Efficacy and Cross-Protection Capacity of DNA vs. Peptide-Based Vaccines in a Murine Model.International journal of molecular sciences · 2023Article
- Vitamin D status, vitamin D receptor gene polymorphism, and haplotype in patients with cutaneous leishmaniasis: Correlation with susceptibility and parasite load index.PLoS neglected tropical diseases · 2023Article
- The Possible Role of Selected Vitamins and Minerals in the Therapeutic Outcomes of Leishmaniasis.Biological trace element research · 2023Review
- Evaluation of serum 25-hydroxyvitamin D, C-reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis.Journal of veterinary internal medicine · 2023Article
- The immune response in canine and human leishmaniasis and how this influences the diagnosis- a review and assessment of recent research.Frontiers in cellular and infection microbiology · 2023Review
- Serum 25-hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease.Journal of veterinary internal medicine · 2023Article
- The effects of age, sex, breed, diet, reproductive status and housing condition on the amounts of 25(OH) vitamin D in the serum of healthy dogs: Reference values.Veterinary medicine and science · 2022Article
- Canine Leishmaniasis: Update on Epidemiology, Diagnosis, Treatment, and Prevention.Veterinary sciences · 2022Review
- The association between single nucleotide polymorphism in vitamin D receptor and calcium oxalate urolithiasis in dogs.Journal of veterinary internal medicine · 2021Article
- Vitamins A and D and Zinc Affect the Leshmanicidal Activity of Canine Spleen Leukocytes.Animals : an open access journal from MDPI · 2021Article
- Vitamin d and leishmaniasis: Neither seasonal nor risk factor in canine host but potential adjuvant treatment through cbd103 expression.PLoS neglected tropical diseases · 2021Article
- Serum 25-hydroxyvitamin D concentration and infectious respiratory disease complex in shelter dogs.Journal of veterinary internal medicine · 2021Article
- The Role of Vitamin D in Small Animal Bone Metabolism.Metabolites · 2020Review
- Vitamin D increases killing of intracellularParasitology · 2020Article
- The balancing act: Immunology of leishmaniosis.Research in veterinary science · 2020Review
- Article
- Effects of calcitriol on oxidative burst, phagocytic function, and leukocyte cytokine production in shelter dogs.Canine medicine and genetics · 2020Article
- Vitamin D status in dogs with babesiosis.The Onderstepoort journal of veterinary research · 2019Article
- Cathelicidin Contributes to the Restriction ofFrontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between vitamin D deficiency and the risk of suffering from a plethora of health disorders, ranging from autoimmune processes to infectious diseases has been widely described. Nonetheless, the potential role of vitamin D in visceral leishmaniasis remains uncharacterized. In the Mediterranean basin, where the dog is leishmania's main peri-domestic reservoir, control measures against the canine disease have shown beneficial effects on the incidence of human leishmaniasis. In this study, we measured the vitamin D levels in serum samples from a cohort of 68 healthy and disease dogs from a highly endemic area and we have also studied the relationship of these levels with parasitological and immunological parameters. The sick dogs presented significantly lower (P < 0.001) vitamin D levels (19.6 ng/mL) than their non-infected (31.8 ng/mL) and the asymptomatic counterparts (29.6 ng/mL). In addition, vitamin D deficiency correlated with several parameters linked to leishmaniasis progression. However, there was no correlation between vitamin D levels and the Leishmania-specific cellular immune response. Moreover, both the leishmanin skin test and the IFN-γ levels displayed negative correlations with serological, parasitological and clinical signs. Further studies to determine the functional role of vitamin D on the progression and control of canine leishmaniasis are needed.
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