ArticleScientific reports2017
Allopregnanolone mediates the exacerbation of Tourette-like responses by acute stress in mouse models.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications.Frontiers in neuroendocrinology · 2026Review
- Clinical Features, Mechanisms, and Management of Anxiety in Youth with Tic Disorders: A Narrative Review.Neuropsychiatric disease and treatment · 2026Review
- The role of neuroactive steroids in psychiatric and neurological disorders: Neurobiology and therapeutic perspectives.Neuroscience and biobehavioral reviews · 2025Review
- Tic-related behaviors in Celsr3 mutant mice are contributed by alterations of striatal DMolecular psychiatry · 2025Article
- Relationships between the menstrual cycle and neuropsychiatric and physical symptoms in females with Tourette syndrome.Frontiers in neurology · 2025Article
- The role of neuroactive steroids in tic disorders.Neuroscience and biobehavioral reviews · 2024Review
- Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting.Brain research bulletin · 2022Article
- Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?Journal of neuroendocrinology · 2022Review
- Allopregnanolone: An overview on its synthesis and effects.Journal of neuroendocrinology · 2022Review
- The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder.The Journal of clinical investigation · 2021Article
- The α6 GABABiomolecules · 2021Article
- Neurobehavioural complications of sleep deprivation: Shedding light on the emerging role of neuroactive steroids.Journal of neuroendocrinology · 2020Review
- Isoallopregnanolone reduces tic-like behaviours in the D1CT-7 mouse model of Tourette syndrome.Journal of neuroendocrinology · 2020Article
- Allopregnanolone is required for prepulse inhibition deficits induced by DPsychoneuroendocrinology · 2019Article
- Repurposing steroidogenesis inhibitors for the therapy of neuropsychiatric disorders: Promises and caveats.Neuropharmacology · 2019Review
- Behavioral fragmentation in the D1CT-7 mouse model of Tourette's syndrome.CNS neuroscience & therapeutics · 2018Article
- Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors.Psychoneuroendocrinology · 2018Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple tics and sensorimotor abnormalities, the severity of which is typically increased by stress. The neurobiological underpinnings of this exacerbation, however, remain elusive. We recently reported that spatial confinement (SC), a moderate environmental stressor, increases tic-like responses and elicits TS-like sensorimotor gating deficits in the D1CT-7 mouse, one of the best-validated models of TS. Here, we hypothesized that these adverse effects may be mediated by neurosteroids, given their well-documented role in stress-response orchestration. Indeed, SC increased the levels of progesterone, as well as its derivatives 5α-dihydroprogesterone and allopregnanolone, in the prefrontal cortex (PFC) of D1CT-7 mice. Among these steroids, however, only allopregnanolone (5-15 mg/kg, IP) dose-dependently exacerbated TS-like manifestations in D1CT-7, but not wild-type littermates; these effects were countered by the benchmark anti-tic therapy haloperidol (0.3 mg/kg, IP). Furthermore, the phenotypic effects of spatial confinement in D1CT-7 mice were suppressed by finasteride (25-50 mg/kg, IP), an inhibitor of the main rate-limiting enzyme in allopregnanolone synthesis. These findings collectively suggest that stress may exacerbate TS symptoms by promoting allopregnanolone synthesis in the PFC, and corroborate previous clinical results pointing to finasteride as a novel therapeutic avenue to curb symptom fluctuations in TS.
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