Evidence map›Paper›PMID 28611362›Full record

ArticleScientific reports2017

Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits.

Jiangming Yu, Lizhang Xu, Kai Li, Ning Xie, Yanhai Xi, Yang Wang, Xuebin Zheng, Xiongsheng Chen, Meiyan Wang, Xiaojian Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiangming YuDepartment of Orthopaedics, Changzheng Hospital of Second Military Medical University, Shanghai, 200003, China. yjm_st@163.com.
Lizhang XuDepartment of Orthopaedics, Changzheng Hospital of Second Military Medical University, Shanghai, 200003, China.
Kai LiKey Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Ning XieDepartment of Orthopaedics, Changzheng Hospital of Second Military Medical University, Shanghai, 200003, China.
Yanhai XiDepartment of Orthopaedics, Changzheng Hospital of Second Military Medical University, Shanghai, 200003, China.
Yang WangDepartment of Orthopaedics, Changzheng Hospital of Second Military Medical University, Shanghai, 200003, China.
Xuebin ZhengKey Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Xiongsheng ChenDepartment of Orthopaedics, Changzheng Hospital of Second Military Medical University, Shanghai, 200003, China.
Meiyan WangShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. 061022049@fudan.edu.cn.
Xiaojian YeDepartment of Orthopaedics, Changzheng Hospital of Second Military Medical University, Shanghai, 200003, China. yespine@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surface-modified metal implants incorporating different ions have been employed in the biomedical field as bioactive dental implants with good osseointegration properties. However, the molecular mechanism through which surface coatings exert the biological activity is not fully understood, and the effects have been difficult to achieve, especially in the osteopenic bone. In this study, We examined the effect of zinc-modified calcium silicate coatings with two different Zn contents to induce osteogenic differentiation of rat bone marrow-derived pericytes (BM-PCs) and osteogenetic efficiency in ovariectomised rabbits. Ti-6Al-4V with zinc-modified calcium silicate coatings not only enhanced proliferation but also promoted osteogenic differentiation and mineralized matrix deposition of rat BM-PCs as the zinc content and culture time increased in vitro. The associated molecular mechanisms were investigated by Q-PCR and Western blotting, revealing that TGF-β/Smad signaling pathway plays a direct and significant role in regulating BM-PCs osteoblastic differentiation on Zn-modified coatings. Furthermore, in vivo results that revealed Zn-modified calcium silicate coatings significantly promoted new bone formation around the implant surface in osteopenic rabbits as the Zn content and exposure time increased. Therefore, Zn-modified calcium silicate coatings can improve implant osseointegration in the condition of osteopenia, which may be beneficial for patients suffering from osteoporosis-related fractures.

Indexed as

OsseointegrationOsteogenesisAnimalsBone Diseases, MetabolicCalcium CompoundsCell DifferentiationCells, CulturedCoated Materials, BiocompatibleFemalePericytesRabbitsSignal TransductionSilicatesSmad ProteinsTransforming Growth Factor betaZincCalcium Compoundscalcium silicateCoated Materials, BiocompatibleSilicatesSmad ProteinsTransforming Growth Factor betaZinc

Identifiers

PMID28611362
PMCPMC5469779

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.