Evidence map›Paper›PMID 28611253›Full record

ArticleRNA (New York, N.Y.)2017

Nate J Fry, Brittany A Law, Olga R Ilkayeva, Christopher L Holley, Kyle D Mansfield

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 116 citations in OpenAlex.

  1. Article
  2. Review
  3. Quality control and signaling pathways at stalled ribosomes.Experimental & molecular medicine · 2026
    Review
  4. Review
  5. Review
  6. mCell · 2025
    Article
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  8. Article
  9. Loss ofInternational journal of molecular sciences · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Insights into the role of RNA mGenes & diseases · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Nate J FryBiochemistry and Molecular Biology Department, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA.
Brittany A LawDepartment of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
Olga R IlkayevaDuke Molecular Physiology Institute, Duke University, Durham, North Carolina 27701, USA.
Christopher L HolleyDepartment of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.ORCID 0000-0002-2870-3352
Kyle D MansfieldBiochemistry and Molecular Biology Department, Brody School of Medicine, East Carolina University, Greenville, North Carolina 27834, USA.ORCID 0000-0002-5498-9876
Duke Medical Center · USEast Carolina University · USDuke University · US

Funding

MULTIDISCIPLINARY HEART &VASCULAR DISEASEST32HL007101 · NHLBI · DUKE UNIVERSITY · PI FREEDMAN, NEIL J. · 1985 to 2020
$9.8M
SNORNAS ARE ESSENTIAL MEDIATORS OF ROS SIGNALING IN CARDIOVASCULAR CELLSK08HL114889 · NHLBI · WASHINGTON UNIVERSITY · PI HOLLEY, CHRISTOPHER LEE · 2012 to 2016
$614k
NHLBI NIH HHS K08 HL114889NHLBI NIH HHS T32 HL007101
6 · The paper itself

Abstract

Post-transcriptional regulation of mRNA during oxygen deprivation, or hypoxia, can affect the survivability of cells. Hypoxia has been shown to increase stability of a subset of ischemia-related mRNAs, including VEGF. RNA binding proteins and miRNAs have been identified as important for post-transcriptional regulation of individual mRNAs, but corresponding mechanisms that regulate global stability are not well understood. Recently, mRNA modification by

Indexed as

AdenosineGene Expression RegulationHEK293 CellsHumansHypoxiaMethylationProtein BiosynthesisRNA, MessengerRNA Processing, Post-TranscriptionalRNA StabilityAdenosineN-methyladenosineRNA, MessengerhypoxiamethyltransferasemRNA stabilizationN6-methyladenosinepost-transcriptional regulation

Identifiers

PMID28611253
PMCPMC5558913
OpenAlexW2627007286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.