ReviewProceedings of the National Academy of Sciences of the United States of America2017
Inhibitory engrams in perception and memory.
Review in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortical control of chandelier cells in neural codes.Frontiers in cellular neuroscience · 2022Pooled it
- ICER-Controlled inhibitory plasticity of amygdala engram neurons regulates fear memory precision.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Retinotopic coding organizes the interaction between internally and externally oriented brain networks.eLife · 2026Article
- The role of GABANeuroscience and biobehavioral reviews · 2026Review
- Predicting individual differences of fear and cognitive learning and extinction.Nature communications · 2026Article
- Neuroligin-2-Dependent Adhesion Defines a Molecular Checkpoint for Inhibitory Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dynamical modeling of individual sensory reactivity and habituation learning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Identification of somatostatinProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Noradrenaline causes a spread of association in the hippocampal cognitive map.Nature communications · 2026Article
- Engram Synapses and Synapse Dynamics in Memory Processing.Journal of neurochemistry · 2026Review
- A Closed-Loop-Capable Neural Interface Platform for Deep Brain Modulation via Integrated Non-Viral Gene Delivery, NIR Optogenetics, and Electrophysiological Recording.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Modular inhibitory coding in binary networks.Frontiers in network physiology · 2026Article
- Satellite microglia gate neuronal excitability by shielding inhibitory synapses in adult brain.bioRxiv : the preprint server for biology · 2025Article
- Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP.PLoS computational biology · 2025Article
- Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex.eLife · 2025Article
- Plasticity of human resilience mechanisms.Science advances · 2025Article
- Effective connectivity between the medial temporal lobes and early visual cortex modulated by unrestricted viewing predicts memory retrieval and gaze reinstatement.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Resolving inconsistent effects of tDCS on learning using a homeostatic structural plasticity model.Frontiers in network physiology · 2025Article
- Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice.Molecular psychiatry · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Nervous systems use excitatory cell assemblies to encode and represent sensory percepts. Similarly, synaptically connected cell assemblies or "engrams" are thought to represent memories of past experience. Multiple lines of recent evidence indicate that brain systems create and use inhibitory replicas of excitatory representations for important cognitive functions. Such matched "inhibitory engrams" can form through homeostatic potentiation of inhibition onto postsynaptic cells that show increased levels of excitation. Inhibitory engrams can reduce behavioral responses to familiar stimuli, thereby resulting in behavioral habituation. In addition, by preventing inappropriate activation of excitatory memory engrams, inhibitory engrams can make memories quiescent, stored in a latent form that is available for context-relevant activation. In neural networks with balanced excitatory and inhibitory engrams, the release of innate responses and recall of associative memories can occur through focused disinhibition. Understanding mechanisms that regulate the formation and expression of inhibitory engrams in vivo may help not only to explain key features of cognition but also to provide insight into transdiagnostic traits associated with psychiatric conditions such as autism, schizophrenia, and posttraumatic stress disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.