ArticleCirculation research2017
Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes.
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In one paragraph
Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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45citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Hypoxia classifier for transcriptome datasets.BMC bioinformatics · 2022Pooled it
- The role of pericytes in homeostasis and cardiovascular disease: A comprehensive review.Journal of advanced research · 2026Review
- Walras modulates sex-dependent endoplasmic reticulum stress in cardiomyopathy.Frontiers in physiology · 2026Article
- Overview of exosomal non-coding RNAs in cardiovascular disease using high throughput sequencing.European journal of pharmacology · 2025Review
- LncRNAs Are Key Regulators of Transcription Factor-Mediated Endothelial Stress Responses.International journal of molecular sciences · 2024Review
- Endoplasmic reticulum stress in diseases.MedComm · 2024Review
- Profiling and Bioinformatics Analyses of Hypoxia-Induced Differential Expression of Long Non-coding RNA in Glioblastoma Multiforme Cells.Biochemical genetics · 2024Article
- Role of long noncoding RNAs in diabetes-associated peripheral arterial disease.Cardiovascular diabetology · 2024Review
- Long non-coding RNAs in cardiac hypertrophy and heart failure: functions, mechanisms and clinical prospects.Nature reviews. Cardiology · 2024Review
- Underlying mechanisms of ketotherapy in heart failure: current evidence for clinical implementations.Frontiers in pharmacology · 2024Review
- Partial Mural Cell Ablation Disrupts Coronary Vasculature Integrity and Induces Systolic Dysfunction.Journal of the American Heart Association · 2023Article
- LncRNAs and CircRNAs in Endoplasmic Reticulum Stress: A Promising Target for Cardiovascular Disease?International journal of molecular sciences · 2023Review
- The ideal treatment timing for diabetic retinopathy: the molecular pathological mechanisms underlying early-stage diabetic retinopathy are a matter of concern.Frontiers in endocrinology · 2023Review
- LncRNAs associated with oxidative stress in diabetic wound healing: Regulatory mechanisms and application prospects.Theranostics · 2023Review
- Long noncoding RNA Gm2694 drives depressive-like behaviors in male mice by interacting with GRP78 to disrupt endoplasmic reticulum homeostasis.Science advances · 2022Article
- Upregulation of PCED1B-AS1 in proliferative diabetic retinopathy and its involvement in retinal vascular endothelial cell proliferation.BMC ophthalmology · 2022Article
- Metformin-dependent variation of microglia phenotype dictates pericytes maturation under oxygen-glucose deprivation.Tissue barriers · 2022Article
- FGF21 alleviates pulmonary hypertension by inhibiting mTORC1/EIF4EBP1 pathway via H19.Journal of cellular and molecular medicine · 2022Article
- Myocardial oedema: pathophysiological basis and implications for the failing heart.ESC heart failure · 2022Review
- The Role of Pericytes in Ischemic Stroke: Fom Cellular Functions to Therapeutic Targets.Frontiers in molecular neuroscience · 2022Review
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Authors and funding
19 authors at 7 institutions in 3 countries.
Florian C BischoffFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Astrid WernerFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
David JohnFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Jes-Niels BoeckelFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Maria-Theodora MelissariFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Phillip GroteFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Simone F GlaserFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Shemsi DemolliFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Shizuka UchidaFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Katharina M MichalikFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Benjamin MederFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Hugo A KatusFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Jan HaasFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Wei ChenFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Soni S PullamsettiFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Werner SeegerFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Andreas M ZeiherFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Stefanie DimmelerFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.). dimmeler@em.uni-frankfurt.de Christoph.Zehendner@gmail.com.
Christoph M ZehendnerFrom the Institute of Cardiovascular Regeneration, Centre of Molecular Medicine (F.C.B., A.W., D.J., M.-T.M., P.G., S.F.G., S.D., S.U., K.M.M., S.D., C.M.Z.); ZIM III, Department of Cardiology (F.C.B., A.W., S.F.G., A.M.Z., C.M.Z.), Goethe University, Frankfurt am Main, Germany; Department of Internal Medicine III, University of Heidelberg, Germany (J.-N.B., B.M., H.A.K., J.H.); DZHK (Deutsches Zentrum für Herz-Kreislaufforschung), Berlin, Germany (F.C.B., D.J., J.-N.B., S.D., S.U., B.M., H.A.K., J.H., W.C., A.M.Z., S.D., C.M.Z.); Cardiovascular Innovation Institute, University of Louisville, KY (S.U.); Laboratory for Novel Sequencing Technology, Functional and Medical Genomics, Berlin Institute for Medical Systems Biology, Max-Delbrück-Centrum für Molekulare Medizin, Germany (W.C.); Department of Biology, Southern University of Science and Technology, Shenzhen, China (W.C.); Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany (S.S.P., W.S.); Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the DZL, Justus Liebig University, Germany (S.S.P., W.S.).
Max Planck Institute for Heart and Lung Research · DEHeidelberg University · DECardiovascular Innovation Institute · USUniversity of Louisville · USGerman Center for Lung Research · DEGoethe University Frankfurt · DESouthern University of Science and Technology · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalePericytes are essential for vessel maturation and endothelial barrier function. Long noncoding RNAs regulate many cellular functions, but their role in pericyte biology remains unexplored.
objectiveHere, we investigate the effect of hypoxia-induced endoplasmic reticulum stress regulating long noncoding RNAs (HypERlnc, also known as ENSG00000262454) on pericyte function in vitro and its regulation in human heart failure and idiopathic pulmonary arterial hypertension. METHODS AND
resultsRNA sequencing in human primary pericytes identified hypoxia-regulated long noncoding RNAs, including HypERlnc. Silencing of HypERlnc decreased cell viability and proliferation and resulted in pericyte dedifferentiation, which went along with increased endothelial permeability in cocultures consisting of human primary pericyte and human coronary microvascular endothelial cells. Consistently, Cas9-based transcriptional activation of HypERlnc was associated with increased expression of pericyte marker genes. Moreover, HypERlnc knockdown reduced endothelial-pericyte recruitment in Matrigel assays (
conclusionsHere, we show that HypERlnc regulates human pericyte function and the endoplasmic reticulum stress response. In addition, RNA sequencing analyses in conjunction with reduced expression of HypERlnc in heart failure and correlation with pericyte markers in idiopathic pulmonary arterial hypertension indicate a role of HypERlnc in human cardiopulmonary disease.
Indexed as
AnimalsBase SequenceCell HypoxiaCoculture TechniquesEndoplasmic Reticulum StressEndothelial CellsHeart FailureHumansHuman Umbilical Vein Endothelial CellsHypertension, PulmonaryMiceMice, Inbred C57BLPericytesRandom AllocationRNA, Long NoncodingRNA, Long Noncodingcardiovascular diseasesheart diseasespericytespulmonary heart diseaseRNA, long noncoding
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