Evidence map›Paper›PMID 28611053›Full record

ArticleDiabetes care2017

The rs7903146 Variant in the

Catrina Cropano, Nicola Santoro, Leif Groop, Chiara Dalla Man, Claudio Cobelli, Alfonso Galderisi, Romy Kursawe, Bridget Pierpont, Martina Goffredo, Sonia Caprio

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 3 pooled it
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
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  15. Association ofDiagnostics (Basel, Switzerland) · 2025
    Article
  16. Review
  17. Article
  18. Review
  19. International journal of medical sciences · 2025
    Article
  20. Interaction between theFrontiers in nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Catrina CropanoDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
Nicola SantoroDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.ORCID 0000-0001-6437-4173
Leif GroopDepartment of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmo, Sweden.
Chiara Dalla ManDepartment of Information Engineering, University of Padua, Padua, Italy.
Claudio CobelliDepartment of Information Engineering, University of Padua, Padua, Italy.
Alfonso GalderisiDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
Romy KursaweThe Jackson Laboratory, Farmington, CT.
Bridget PierpontDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
Martina GoffredoDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
Sonia CaprioDivision of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT sonia.caprio@yale.edu.ORCID 0000-0002-7523-5053
Yale University · USUniversity of Padua · ITJackson Laboratory · USLund University · SE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
METABOLIC PREDICTORS AND MARKERS OF CHILDHOOD OBESITYR01HD028016 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 1991 to 2024
$8.9M
Pathogenesis of youth onset pre-diabetes and Type 2 diabetesR01DK111038 · NIDDK · YALE UNIVERSITY · PI CAPRIO, SONIA · 2016 to 2025
$7.0M
Study to Investigate the Pathophysiology of Type 2 Diabetes in YouthR01HD040787 · NICHD · YALE UNIVERSITY · PI CAPRIO, SONIA · 2000 to 2014
$5.6M
NCATS NIH HHS UL1 TR001863NCRR NIH HHS UL1 RR024139NICHD NIH HHS R01 HD028016NICHD NIH HHS R01 HD040787NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK111038
6 · The paper itself

Abstract

objectiveIn this study, we aimed to explore the mechanism by which RESEARCH DESIGN AND

methodsThe rs7903146 variant in the

resultsThe

conclusionsThe rs7903146 variant in the

Indexed as

AdolescentAllelesBody Mass IndexChildCohort StudiesDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGenetic Predisposition to DiseaseGlucose IntoleranceGlucose Tolerance TestHumansInsulinInsulin ResistanceInsulin-Secreting CellsInsulin SecretionInsulinTCF7L2 protein, humanTranscription Factor 7-Like 2 Protein

Identifiers

PMID28611053
PMCPMC5521977
OpenAlexW2626304445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.