ArticleAmerican journal of physiology. Endocrinology and metabolism2017
The intestinal-renal axis for arginine synthesis is present and functional in the neonatal pig.
Article in American journal of physiology. Endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Relationship between arginine intake in parenteral nutrition and preterm neonatal population plasma arginine concentrations: a systematic review.Nutrition reviews · 2019Pooled it
- L-Citrulline in Maternal-Fetal and Neonatal Health: Metabolic Mechanisms and Emerging Therapeutic Applications.Nutrients · 2026Review
- Analysis of catabolic products of L-arginine; L-ornithine and L-citrulline and the residual L-arginine using the HPLC and LC-MS.PloS one · 2026Article
- Nonessential amino acid is not nonessential in geriatric patients: implications for maxillofacial wound healing and bone repair.Maxillofacial plastic and reconstructive surgery · 2025Review
- Arginine: at the crossroads of nitrogen metabolism.The EMBO journal · 2025Review
- Low feed intake at weaning reduces intestinal glutathione levels and promotes cysteine oxidation to taurine in pigs.Journal of animal science · 2024Article
- Effects ofFrontiers in microbiology · 2024Article
- Article
- Dietary supplementation with 2-hydroxy-4-methyl(thio) butanoic acid and DL-methionine improves productive performance, egg quality and redox status of commercial laying ducks.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Crosstalk between arginine, glutamine, and the branched chain amino acid metabolism in the tumor microenvironment.Frontiers in oncology · 2023Review
- A Deep Insight Into Regulatory T Cell Metabolism in Renal Disease: Facts and Perspectives.Frontiers in immunology · 2022Review
- Comparative plasma and urine metabolomics analysis of juvenile and adult canines.Frontiers in veterinary science · 2022Article
- Citrulline, Biomarker of Enterocyte Functional Mass and Dietary Supplement. Metabolism, Transport, and Current Evidence for Clinical Use.Nutrients · 2021Review
- Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs.American journal of physiology. Endocrinology and metabolism · 2021Article
- Rumen-protected arginine in ewe lambs: effects on circulating serum amino acids and carotid artery hemodynamics.Journal of animal science · 2020Article
- Developmental changes in the utilization of citrulline by neonatal pigs.American journal of physiology. Renal physiology · 2020Article
- Feeding a reduced protein diet with a near ideal amino acid profile improves amino acid efficiency and nitrogen utilization for milk production in sows1,2.Journal of animal science · 2019Article
- Citrulline Generation Test: What Does It Measure?JPEN. Journal of parenteral and enteral nutrition · 2019Article
- Regulation of Muscle Growth in Early Postnatal Life in a Swine Model.Annual review of animal biosciences · 2019Review
- SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/obCardiovascular diabetology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The intestinal-renal axis for endogenous arginine synthesis is an interorgan process in which citrulline produced in the small intestine is utilized by the kidney for arginine synthesis. The function of this axis in neonates has been questioned because during this period the enzymes needed for arginine synthesis argininosuccinate synthase (ASS1) and lyase (ASL) are present in the gut. However, evidence of high plasma citrulline concentrations in neonates suggests otherwise. We quantified in vivo citrulline production in premature (10 days preterm), neonatal (7 days old), and young pigs (35 days old) using citrulline tracers. Neonatal pigs had higher fluxes (69 µmol·kg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.